CAS 198470-85-8

Parecoxib sodium

Description:

Parecoxib sodium is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the class of selective cyclooxygenase-2 (COX-2) inhibitors. It is primarily used for the management of postoperative pain and is administered parenterally. As a prodrug, parecoxib is converted in the body to its active form, valdecoxib, which exerts its analgesic and anti-inflammatory effects by selectively inhibiting COX-2, thereby reducing the production of prostaglandins involved in pain and inflammation. Parecoxib sodium is characterized by its sodium salt form, which enhances its solubility in aqueous solutions, making it suitable for intravenous administration. The substance is typically presented as a white to off-white crystalline powder and is stable under normal conditions. Its pharmacokinetics include rapid absorption and metabolism, with a relatively short half-life. While effective for pain relief, parecoxib sodium, like other NSAIDs, may carry risks of cardiovascular and gastrointestinal side effects, necessitating careful patient selection and monitoring during use.

Formula:C₁₉H₁₇N₂NaO₄S

InChI:InChI=1/C19H18N2O4S.Na/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;/h4-12H,3H2,1-2H3,(H,21,22);/q;+1/p-1

InChI key:InChIKey=IMBMHWVEMVJSIQ-UHFFFAOYSA-N

SMILES:CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(S(NC(CC)=O)(=O)=O)C=C3.[Na]

Synonyms:

Dynastat
N-[4-(5-Methyl-3-Phenylisoxazol-4-YL)Phenylsulfonyl]Propionamide, sodium salt
Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodium salt
Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodium salt (1:1)
Rayzon
Sc 69124A
Parecoxib sodium
（Intermediate in China ONLY）
N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanamide sodium hydride
Parecoxib sodiuM sal
sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide
PARECOXIB SODIUM USP/EP/BP
N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide Sodium Salt（Parecoxib Sodium）
parexib sodium
Parecoxib Sodium Impurity
Parecoxib Impurity 64
sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonysodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl) (propionyl)amidel) (propionyl)amide
Parecoxib Impurity 22 Sodium Salt
Parecoxib sodiuM salt
Parecoxib CRS
Parecoxib sodiuM cloth
Parecoxib-011-Na
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