CAS 198470-85-8

Parecoxib sodium

Description:

Parecoxib sodium is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the class of selective cyclooxygenase-2 (COX-2) inhibitors. It is primarily used for the management of postoperative pain and is administered parenterally. As a prodrug, parecoxib is converted in the body to its active form, valdecoxib, which exerts its analgesic and anti-inflammatory effects by selectively inhibiting COX-2, thereby reducing the production of prostaglandins involved in pain and inflammation. Parecoxib sodium is characterized by its sodium salt form, which enhances its solubility in aqueous solutions, making it suitable for intravenous administration. The substance is typically presented as a white to off-white crystalline powder and is stable under normal conditions. Its pharmacokinetics include rapid absorption and metabolism, with a relatively short half-life. While effective for pain relief, parecoxib sodium, like other NSAIDs, may carry risks of cardiovascular and gastrointestinal side effects, necessitating careful patient selection and monitoring during use.

Formula: C₁₉H₁₇N₂NaO₄S

InChI: InChI=1/C19H18N2O4S.Na/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;/h4-12H,3H2,1-2H3,(H,21,22);/q;+1/p-1

InChI key: InChIKey=IMBMHWVEMVJSIQ-UHFFFAOYSA-N

SMILES: CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(S(NC(CC)=O)(=O)=O)C=C3.[Na]

Synonyms:

• Dynastat
• N-[4-(5-Methyl-3-Phenylisoxazol-4-YL)Phenylsulfonyl]Propionamide, sodium salt
• Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodium salt
• Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodium salt (1:1)
• Rayzon
• Sc 69124A
• Parecoxib sodium
• （Intermediate in China ONLY）
• N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanamide sodium hydride
• Parecoxib sodiuM sal
• sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide
• PARECOXIB SODIUM USP/EP/BP
• N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide Sodium Salt（Parecoxib Sodium）
• parexib sodium
• Parecoxib Sodium Impurity
• Parecoxib Impurity 64
• sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonysodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl) (propionyl)amidel) (propionyl)amide
• Parecoxib Impurity 22 Sodium Salt
• Parecoxib sodiuM salt
• Parecoxib CRS
• Parecoxib sodiuM cloth
• Parecoxib-011-Na

Parecoxib Sodium

CAS: 198470-85-8

Parecoxib Sodium

Formula: C₁₉H₁₇N₂NaO₄S

Purity: 98%

Molecular weight: 392.4

Ref: 54-OR1026325

Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodium salt (1:1)

CAS: 198470-85-8

Formula: C₁₉H₁₇N₂NaO₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 392.4040

Ref: IN-DA002BIZ

Parecoxib Sodium Salt

CAS: 198470-85-8

Formula: C₁₉H₁₇N₂O₄S·Na

Color and Shape: White To Off-White Solid

Molecular weight: 369.42 22.99

Ref: 4Z-P-139002

Parecoxib sodium salt

CAS: 198470-85-8

Formula: ClNa

Molecular weight: 58.44

Ref: 7W-GP1473

Parecoxib Sodium

CAS: 198470-85-8

Formula: C₁₉H₁₇N₂NaO₄S

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 392.40

Ref: 3B-P3100

Parecoxib Sodium

Controlled Product

CAS: 198470-85-8

Formula: C₁₉H₁₇N₂O₄S·Na

Color and Shape: White

Molecular weight: 392.40

Ref: 86-MM3660.00

Parecoxib sodium

CAS: 198470-85-8

Parecoxib sodium is a prodrug of Valdecoxib and a selective COX-2 inhibitor prodrug and CB1 agonist (EC50=2.4 µM), alleviate pain and inflammation.

Formula: C₁₉H₁₇N₂NaO₄S

Purity: 98%

Color and Shape: White Solid

Molecular weight: 392.4

Ref: TM-T1780L

Parecoxib Sodium

Controlled Product

CAS: 198470-85-8

Applications Anti-inflammatory, analgesic.
References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Polascheck, N., et al.: Exper. Neurol., 224, 219 (2010), Gudbjornsson, B., et al.: Eur. J. Clin. Pharmacol., 66, 619 (2010),

Formula: C₁₉H₁₇N₂O₄S·Na

Color and Shape: Neat

Molecular weight: 392.4

Ref: TR-P193275

Parecoxib Sodium Salt

CAS: 198470-85-8

Formula: C₁₉H₁₇N₂O₄SNa

Molecular weight: 369.4 : 23.0

Ref: ST-EA-CP-P37007

PARECOXIB SODIUM

CAS: 198470-85-8

Purity: 97.0%

Molecular weight: 392.3999938964844

Ref: 10-F468398

Parecoxib-d5 Sodium

Controlled Product

CAS: 198470-85-8

Applications Labelled Parecoxib (P193275). Anti-inflammatory, analgesic.
References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Polascheck, N., et al.: Exper. Neurol., 224, 219 (2010), Gudbjornsson, B., et al.: Eur. J. Clin. Pharmacol., 66, 619 (2010),

Formula: C₁₉H₁₂D₅N₂NaO₄S

Color and Shape: Neat

Molecular weight: 397.43

Ref: TR-P193277

Parecoxib sodium salt - Bio-X ™

Controlled Product

CAS: 198470-85-8

Parecoxib is a COX-2 inhibitor and belongs to the group of pharmacological agents. It is a prodrug of valdecoxib that is used for the treatment of osteoarthritis and rheumatoid arthritis, as well as other conditions where the reduction in pain and inflammation are desired.

Formula: C₁₉H₁₇N₂NaO₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 392.41 g/mol

Ref: 3D-BP164231

Parecoxib sodium

Controlled Product

CAS: 198470-85-8

COX-2 inhibitor; prodrug of valdecoxib

Formula: C₁₉H₁₈N₂O₄S·Na

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 394.42 g/mol

Ref: 3D-FP65122