CAS 198481-32-2

Bazedoxifene

Description:

Bazedoxifene is a selective estrogen receptor modulator (SERM) primarily used in the treatment of postmenopausal osteoporosis. It exhibits tissue-selective estrogenic activity, meaning it can mimic estrogen in some tissues while blocking its effects in others. This characteristic makes it beneficial for bone health without the associated risks of estrogen therapy, such as increased breast cancer risk. Bazedoxifene works by binding to estrogen receptors in bone tissue, promoting bone density and reducing the risk of fractures. Its chemical structure includes a phenolic group, which contributes to its receptor-binding properties. Bazedoxifene is typically administered orally and is often combined with conjugated estrogens in therapeutic regimens. The substance has undergone extensive clinical trials to evaluate its efficacy and safety profile, demonstrating a favorable outcome in improving bone mineral density and overall bone health in postmenopausal women. As with any medication, potential side effects and contraindications should be considered, and it is essential for patients to consult healthcare professionals before starting treatment.

Formula: C₃₀H₃₄N₂O₃

InChI: InChI=1S/C30H34N2O3/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31/h6-15,20,33-34H,2-5,16-19,21H2,1H3

InChI key: InChIKey=UCJGJABZCDBEDK-UHFFFAOYSA-N

SMILES: C(N1C(=C(C)C=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(OCCN5CCCCCC5)C=C4

Synonyms:

• 1-((4-(2-Hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
• 1-[[4-[2-(Azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol
• 1-{4-[2-(azepan-1-yl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
• 1H-Indol-5-ol, 1-((4-(2-(hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-
• Bazedoxifene
• Bazedoxifeno
• Bazedoxifeno [INN-Spanish]
• Conbriza
• Tse-424
• Unii-Q16Tt9C5Bk
• Way 140424

Bazedoxifene

CAS: 198481-32-2

Bazedoxifene is an orally active SERM against ERα and ERβ and inhibits IL-6/GP130, applied in postmenopausal osteoporosis and pancreatic cancer research.

Formula: C₃₀H₃₄N₂O₃

Purity: 98.79%

Color and Shape: Yellow Solid

Molecular weight: 470.61

Ref: TM-T2544L

Bazedoxifene

Controlled Product

CAS: 198481-32-2

Formula: C₃₀H₃₄N₂O₃

Color and Shape: Neat

Molecular weight: 470.6

Ref: TR-B129245

Bazedoxifene

CAS: 198481-32-2

Formula: C₃₀H₃₄N₂O₃

Molecular weight: 470.61

Ref: ST-EA-CP-B41000