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CAS 1985605-59-1

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Baloxavir

Description:
Baloxavir marboxil is an antiviral medication primarily used for the treatment of influenza. It functions as a polymerase acidic endonuclease inhibitor, disrupting the viral replication process by preventing the cap-dependent transcription of viral RNA. This mechanism of action distinguishes it from other antiviral agents, such as neuraminidase inhibitors. Baloxavir is administered orally and is notable for its single-dose regimen, which enhances patient compliance. The substance is characterized by its relatively low molecular weight and specific structural features that contribute to its efficacy against various strains of the influenza virus, including those resistant to other antiviral treatments. Baloxavir marboxil is prodrug, meaning it is metabolized in the body to its active form, which is responsible for its antiviral activity. Its safety profile includes common side effects such as headache and gastrointestinal disturbances, but it is generally well-tolerated. The development of baloxavir represents a significant advancement in influenza treatment, particularly in the context of emerging viral resistance.
Formula:C24H19F2N3O4S
InChI:InChI=1S/C24H19F2N3O4S/c25-16-6-5-13-15(20(16)26)12-34-18-4-2-1-3-14(18)21(13)29-19-11-33-10-9-27(19)24(32)22-23(31)17(30)7-8-28(22)29/h1-8,19,21,31H,9-12H2/t19-,21+/m1/s1
InChI key:FIDLLEYNNRGVFR-CTNGQTDRSA-N
SMILES:C1COC[C@@H]2N1C(=O)C3=C(C(=O)C=CN3N2[C@H]4C5=C(CSC6=CC=CC=C46)C(=C(C=C5)F)F)O
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Found 15 products.