CAS 1998725-11-3

Formula: C14H24N4O4

InChI: InChI=1S/C14H24N4O4/c1-4-22-14(21)12(6-5-10(19)8-17-16)18-13(20)11(15)7-9(2)3/h8-9,11-12H,4-7,15H2,1-3H3,(H,18,20)/t11-,12-/m0/s1

InChI key: YZRCHOFKIPHQBW-RYUDHWBXSA-N

SMILES: CCOC(=O)[C@H](CCC(=O)C=[N+]=[N-])NC(=O)[C@H](CC(C)C)N

JHU-083

CAS: 1998725-11-3

JHU-083

Formula: C₁₄H₂₄N₄O₄

Purity: ≥95%

Molecular weight: 312.37

Ref: 54-BUP20964

L-Norleucine, L-leucyl-6-diazo-5-oxo-, ethyl ester

CAS: 1998725-11-3

Formula: C₁₄H₂₄N₄O₄

Purity: 99.53%

Color and Shape: Solid

Molecular weight: 312.3648

Ref: IN-DA01MVLC

JHU-083

CAS: 1998725-11-3

JHU-083 is an investigational therapeutic agent, which is a potent small molecule inhibitor of glutamine metabolism. It originates from academic institutions focused on advancing biomedical research. The mode of action of JHU-083 involves the inhibition of glutaminase, an enzyme critical for converting glutamine to glutamate, a key energy source for proliferating cells. By impeding this metabolic pathway, JHU-083 effectively starves cancer cells of the necessary components for growth and survival.

Formula: C₁₄H₂₄N₄O₄

Purity: Min. 95%

Molecular weight: 312.36 g/mol

Ref: 3D-YED72511

JHU-083

CAS: 1998725-11-3

JHU-083 is a glutaminase antagonist that improves cognition and normalizes aberrant hippocampal glutaminase activity in APOE4 mice.

Formula: C₁₄H₂₄N₄O₄

Purity: 97.89% - 99.53%

Color and Shape: Solid

Molecular weight: 312.3648

Ref: TM-T15613