CAS 200336-86-3

Fmoc-Asp(2-phenylisopropyl ester)-OH

Description:

Fmoc-Asp(2-phenylisopropyl ester)-OH is a chemical compound commonly used in peptide synthesis and research. It is a derivative of aspartic acid, where the amino group is protected by a 9-fluorenylmethoxycarbonyl (Fmoc) group, which is a widely used protective group in solid-phase peptide synthesis. The presence of the 2-phenylisopropyl ester indicates that the carboxylic acid group of aspartic acid is esterified, enhancing its lipophilicity and potentially influencing its reactivity and solubility in organic solvents. This compound typically appears as a white to off-white solid and is soluble in organic solvents like dichloromethane and dimethylformamide. Its structure allows for selective deprotection of the Fmoc group under mild basic conditions, facilitating the stepwise assembly of peptides. The compound is utilized in various biochemical applications, including drug development and the study of protein interactions, due to its ability to mimic natural amino acids while providing unique chemical properties.

Formula: C₂₈H₂₇NO₆

Synonyms:

• Fmoc-Asp(2-phenylisopropylester)-OH
• Fmoc-Asp(O-2-Phipr)-Oh
• FMOC-ASP(O-2-PHIPR)-OH USP/EP/BP
• N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ASPARTIC ACID BETA-2-PHENYLISOPROPYL ESTER
• (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-(2-phenylpropan-2-yloxy)butanoic acid
• N-Fmoc-L-aspartic acid 4-(2-phenyl-2-propyl) ester
• FMOC-ASP(2-PHENYLISOPROPYL ESTER)-OH
• FMoc-Asp(OPp)-OH
• (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-oxo-4-((2-phenylpropan-2-yl)oxy)butanoic acid
• (9H-Fluoren-9-yl)MethOxy]Carbonyl Asp(OPis)-OH
• Fmoc-L-Asp(2-phenylisopropyloxy)-OH
• FMOC-ASP(OPIS)-OH
• N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ASPARTIC ACID BETA-(1,1-DIMETHYL) BENZYL ESTER
• N-ALPHA-FMOC-L-ASPARTIC ACID BETA-2-PHENYLISOPROPYL ESTER
• FMOC-ASP[BZL(ME2)]-OH
• FMOC-ASPARTIC ACID(2-PHENYLISOPROPYL ESTER)
• Fmoc-L-Asp(PP)-OH
• Fmoc-L-aspartic acid β-2-phenylisopropyl ester≥ 99% (HPLC, Chiral purity)
• Fmoc-L-aspartic acid β-2-phenylisopropyl ester
• L-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-(1-methyl-1-phenylethyl) ester
• FMOC-L-ASPARTIC ACID BETA-2-PHENYLISOPROPYL ESTER

Fmoc-Asp(2-phenylisopropyl ester)-OH

CAS: 200336-86-3

An aspartic acid derivative allowing specific side chain deprotection with 1% TFA in dichloromethane. Ocampo et al. applied OPp protection during the synthesis of a peptide-oligonucleotide conjugate and cleaved it with 3% trichloroacetic acid in DCM. The OPp derivative is far less prone towards base-catalyzed aspartimide formation than the OAll, OBzl, or ODmab esters, its stability comes close to the stability of the OtBu ester.

Formula: C₂₈H₂₇NO₆

Purity: 99.53%

Color and Shape: White Powder

Molecular weight: 473.53

Ref: 01-4019087

L-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-(1-methyl-1-phenylethyl) ester

CAS: 200336-86-3

Formula: C₂₈H₂₇NO₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 473.5171

Ref: IN-DA002CPC

Fmoc-L-aspartic acid β-2-phenylisopropyl ester

CAS: 200336-86-3

Formula: C₂₈H₂₇NO₆

Purity: ≥ 99%

Color and Shape: White to off-white powder

Molecular weight: 473.52

Ref: 7W-GX1103

Fmoc-Asp(O-2-PhiPr)-OH

CAS: 200336-86-3

Fmoc-Asp(O-2-PhiPr)-OH

Purity: 97%

Molecular weight: 473.52g/mol

Ref: 54-OR36471

Fmoc-L-aspartic acid beta-2-phenylisopropyl ester

CAS: 200336-86-3

Fmoc-L-aspartic acid beta-2-phenylisopropyl ester is a macrocyclic amino acid with conformational and anti-inflammatory properties. It has been shown to inhibit the proliferation of cancer cells in vitro, as well as the osteolytic, lymphoproliferative, and inflammatory activities in vivo. Fmoc-L-aspartic acid beta-2-phenylisopropyl ester also has antiarrhythmic effects on cardiac tissue that are caused by its ability to bind to chloride channels. This compound also inhibits the production of inflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interleukin 6 (IL6).

Formula: C₂₈H₂₇NO₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 473.52 g/mol

Ref: 3D-FF48558

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-oxo-4-((2-phenylpropan-2-yl)oxy)butanoic acid

CAS: 200336-86-3

Purity: 97%

Molecular weight: 473.5249939

Ref: 10-F616748