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CAS 201341-05-1

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Tenofovir disoproxil

Description:
Tenofovir disoproxil is an antiretroviral medication primarily used in the treatment and prevention of HIV/AIDS and chronic hepatitis B infection. It is a prodrug of tenofovir, which means it is metabolized in the body to its active form. The substance is characterized by its ability to inhibit the reverse transcriptase enzyme, thereby preventing viral replication. Chemically, it is classified as a nucleotide analog and is known for its high oral bioavailability. Tenofovir disoproxil is typically administered in the form of a fumarate salt, enhancing its stability and absorption. The compound is soluble in water and exhibits a relatively long half-life, allowing for once-daily dosing. Its safety profile is generally favorable, although it may be associated with renal toxicity and bone mineral density loss in some patients. As a key component of combination therapy regimens, tenofovir disoproxil has played a significant role in reducing the incidence of HIV transmission and improving the quality of life for individuals living with HIV.
Formula:C19H30N5O10P
InChI:InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1
InChI key:InChIKey=JFVZFKDSXNQEJW-CQSZACIVSA-N
SMILES:C([C@H](OCP(OCOC(OC(C)C)=O)(OCOC(OC(C)C)=O)=O)C)N1C=2C(N=C1)=C(N)N=CN2
Synonyms:
  • 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, 1,9-bis(1-methylethyl) ester, 5-oxide
  • 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(1-methylethyl) ester, 5-oxide
  • 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(1-methylethyl) ester, 5-oxide, (R)-
  • 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine
  • Bis-POC-PMPA
  • Gs 4331
  • TD
  • bis({[(1-methylethoxy)carbonyl]oxy}methyl) {[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}phosphonate
  • Tenofovir disoproxil
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