CAS 201530-41-8
:Deferasirox
Description:
Deferasirox is an oral iron chelator primarily used in the treatment of chronic iron overload, particularly in patients with conditions such as thalassemia or sickle cell disease who require regular blood transfusions. Its chemical formula is C21H18N2O7S, and it functions by binding excess iron in the body, facilitating its excretion through the feces. Deferasirox is characterized by its ability to selectively bind ferric ions, forming stable complexes that reduce iron toxicity and prevent organ damage. The substance is typically administered in tablet form and is known for its relatively favorable side effect profile compared to other iron chelators. Common side effects may include gastrointestinal disturbances, skin rashes, and renal function changes, necessitating regular monitoring of kidney function during treatment. Deferasirox is marketed under various brand names and is recognized for its role in improving the quality of life for patients with iron overload conditions. Its mechanism of action and pharmacokinetics make it a critical component in managing iron overload effectively.
Formula:C21H15N3O4
InChI:InChI=1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,25-26H,(H,27,28)
InChI key:InChIKey=BOFQWVMAQOTZIW-UHFFFAOYSA-N
SMILES:OC1=C(C=2N(N=C(N2)C3=C(O)C=CC=C3)C4=CC=C(C(O)=O)C=C4)C=CC=C1
Synonyms:- 4-[(3Z,5E)-3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoic acid
- 4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid
- 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
- Asunra
- Benzoic acid, 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-
- Exjade
- Icl 670
- Icl 670A
- Jadenu
- Deferasirox
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Found 16 products.
Deferasirox
CAS:Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoiFormula:C21H15N3O4Color and Shape:White PowderMolecular weight:373.10626Deferasirox
CAS:<p>Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.</p>Formula:C21H15N3O4Purity:98.79% - 99.4%Color and Shape:SolidMolecular weight:373.364-[bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
CAS:Formula:C21H15N3O4Purity:98%Color and Shape:SolidMolecular weight:373.3615Deferasirox
CAS:Formula:C21H15N3O4Purity:>98.0%(HPLC)Color and Shape:White to Gray to Brown powder to crystalMolecular weight:373.37Deferasirox
CAS:<p>Tridentate iron chelator</p>Formula:C21H15N3O4Purity:Min. 95%Color and Shape:PowderMolecular weight:373.36 g/molDeferasirox-d4 (major)(Mixture of 6-hydroxyphenyl-d4 isomers)
CAS:Controlled Product<p>Applications Labelled orally active tridentate iron chelator.<br>References Hershko, C., et al.: Blood, 97, 1115 (2001), Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003), Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003),<br></p>Formula:C21D4H11N3O4Color and Shape:NeatMolecular weight:754.772
![4-[bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA002DHE.jpg&w=3840&q=75)
