CAS 201530-41-8: Deferasirox

Description: Deferasirox is an oral iron chelator primarily used in the treatment of chronic iron overload, particularly in patients with conditions such as thalassemia or sickle cell disease who require regular blood transfusions. Its chemical formula is C21H18N2O7S, and it functions by binding excess iron in the body, facilitating its excretion through the feces. Deferasirox is characterized by its ability to selectively bind ferric ions, forming stable complexes that reduce iron toxicity and prevent organ damage. The substance is typically administered in tablet form and is known for its relatively favorable side effect profile compared to other iron chelators. Common side effects may include gastrointestinal disturbances, skin rashes, and renal function changes, necessitating regular monitoring of kidney function during treatment. Deferasirox is marketed under various brand names and is recognized for its role in improving the quality of life for patients with iron overload conditions. Its mechanism of action and pharmacokinetics make it a critical component in managing iron overload effectively.

Formula: C₂₁H₁₅N₃O₄

InChI: InChI=1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,25-26H,(H,27,28)

InChI key: InChIKey=BOFQWVMAQOTZIW-UHFFFAOYSA-N

SMILES: O=C(O)C1=CC=C(C=C1)N2N=C(N=C2C=3C=CC=CC3O)C=4C=CC=CC4O

Synonyms:

• 4-[(3Z,5E)-3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoic acid
• 4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid
• 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
• Asunra
• Benzoic acid, 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-
• Exjade
• Icl 670
• Icl 670A
• Jadenu
• Deferasirox

Deferasirox

CAS: 201530-41-8

• Formula: C₂₁H₁₅N₃O₄
• Purity: >98.0%(HPLC)
• Color and Shape: White to Gray to Brown powder to crystal
• Molecular weight: 373.37

Deferasirox for system suitability CRS

CAS: 201530-41-8

Deferasirox CRS

CAS: 201530-41-8

Deferasirox

CAS: 201530-41-8

Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

• Formula: C₂₁H₁₅N₃O₄
• Color and Shape: White Powder
• Molecular weight: 373.10626

Deferasirox

CAS: 201530-41-8

Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.

• Formula: C₂₁H₁₅N₃O₄
• Purity: 98.79% - 99.4%
• Color and Shape: Solid
• Molecular weight: 373.36

Benzoic acid, 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-

CAS: 201530-41-8

• Formula: C₂₁H₁₅N₃O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 373.3615

Deferasirox

CAS: 201530-41-8

• Purity: 98%
• Molecular weight: 373.36g/mol

Deferasirox

CAS: 201530-41-8

• Purity: 99.89%
• Molecular weight: 373.36g/mol

Deferasirox

CAS: 201530-41-8

• Formula: C₂₁H₁₅N₃O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 373.37

Deferasirox

CAS: 201530-41-8

• Formula: C₂₁H₁₅N₃O₄
• Molecular weight: 373.36

Deferasirox

CAS: 201530-41-8

• Formula: C₂₁H₁₅N₃O₄
• Color and Shape: Neat
• Molecular weight: 373.36

Deferasirox

CAS: 201530-41-8

• Formula: C₂₁H₁₅N₃O₄
• Color and Shape: Neat
• Molecular weight: 373.36

Deferasirox

CAS: 201530-41-8

• Formula: C₂₁H₁₅N₃O₄
• Color and Shape: Neat
• Molecular weight: 373.36

Deferasirox

CAS: 201530-41-8

Tridentate iron chelator

• Formula: C₂₁H₁₅N₃O₄
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 373.36 g/mol

Deferasirox-d4 (major)(Mixture of 6-hydroxyphenyl-d4 isomers)

CAS: 1133425-77-0 1133425-79-2 201530-41-8

Applications Labelled orally active tridentate iron chelator. References Hershko, C., et al.: Blood, 97, 1115 …

• Formula: C₂₁D₄H₁₁N₃O₄
• Color and Shape: Neat
• Molecular weight: 754.772

Deferasirox-d8

CAS: 201530-41-8

• Formula: C₂₁D₈H₇N₃O₄
• Color and Shape: Neat
• Molecular weight: 381.411