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CAS 201530-41-8

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Deferasirox

Description:
Deferasirox is an oral iron chelator primarily used in the treatment of chronic iron overload, particularly in patients with conditions such as thalassemia or sickle cell disease who require regular blood transfusions. Its chemical formula is C21H18N2O7S, and it functions by binding excess iron in the body, facilitating its excretion through the feces. Deferasirox is characterized by its ability to selectively bind ferric ions, forming stable complexes that reduce iron toxicity and prevent organ damage. The substance is typically administered in tablet form and is known for its relatively favorable side effect profile compared to other iron chelators. Common side effects may include gastrointestinal disturbances, skin rashes, and renal function changes, necessitating regular monitoring of kidney function during treatment. Deferasirox is marketed under various brand names and is recognized for its role in improving the quality of life for patients with iron overload conditions. Its mechanism of action and pharmacokinetics make it a critical component in managing iron overload effectively.
Formula:C21H15N3O4
InChI:InChI=1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,25-26H,(H,27,28)
InChI key:InChIKey=BOFQWVMAQOTZIW-UHFFFAOYSA-N
SMILES:OC1=C(C=2N(N=C(N2)C3=C(O)C=CC=C3)C4=CC=C(C(O)=O)C=C4)C=CC=C1
Synonyms:
  • 4-[(3Z,5E)-3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoic acid
  • 4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid
  • 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
  • Asunra
  • Benzoic acid, 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-
  • Exjade
  • Icl 670
  • Icl 670A
  • Jadenu
  • Deferasirox
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Found 19 products.