CAS 202197-26-0

3-Chloro-4-[(3-fluorophenyl)methoxy]benzenamine

Description:

3-Chloro-4-[(3-fluorophenyl)methoxy]benzenamine, with the CAS number 202197-26-0, is an organic compound characterized by its aromatic structure, which includes a chloro substituent and a methoxy group attached to a phenyl ring. This compound features a primary amine functional group, which contributes to its reactivity and potential applications in various chemical reactions, including nucleophilic substitutions. The presence of the fluorophenyl moiety enhances its lipophilicity and may influence its biological activity, making it of interest in medicinal chemistry. The chlorine atom introduces additional electronic effects, potentially affecting the compound's stability and reactivity. Overall, this compound's unique combination of functional groups and substituents suggests potential utility in pharmaceutical development, particularly in the design of targeted therapies or as intermediates in the synthesis of more complex molecules. Its physical properties, such as solubility and melting point, would depend on the specific interactions of these functional groups in various solvents.

Formula: C₁₃H₁₁ClFNO

InChI: InChI=1S/C13H11ClFNO/c14-12-7-11(16)4-5-13(12)17-8-9-2-1-3-10(15)6-9/h1-7H,8,16H2

InChI key: InChIKey=AYPFEYDGZDPAPE-UHFFFAOYSA-N

SMILES: C(OC1=C(Cl)C=C(N)C=C1)C2=CC(F)=CC=C2

Synonyms:

• 3-Chloro-4-(3-fluoro-benzyloxy)-phenylamine
• 3-Chloro-4-(3-fluorobenzyloxy)-aniline
• 3-Chloro-4-[(3-fluorobenzyl)oxy]aniline
• 3-Chloro-4-[(3-fluorophenyl)methoxy]aniline
• 3-Chloro-4-[(3-fluorophenyl)methoxy]benzenamine
• 4-(3-Fluorobenzyloxy)-3-chloroaniline
• Benzenamine, 3-chloro-4-[(3-fluorophenyl)methoxy]-
• [3-Chloro-4-(3-fluorobenzyloxy)phenyl]amine

Benzenamine, 3-​chloro-​4-​[(3-​fluorophenyl)​methoxy]​-

CAS: 202197-26-0

Formula: C₁₃H₁₁ClFNO

Purity: 98%

Color and Shape: Solid

Molecular weight: 251.6839

Ref: IN-DA00283Z

Lapatinib Impurity 18-d4

CAS: 202197-26-0

Formula: C₁₃H₇D₄ClFNO

Color and Shape: White To Off-White Solid

Molecular weight: 255.71

Ref: 4Z-L-2517

Lapatinib Impurity 18

CAS: 202197-26-0

Formula: C₁₃H₁₁ClFNO

Color and Shape: Pale Grey Solid

Molecular weight: 251.69

Ref: 4Z-L-2524

3-Chloro-4-(3-fluorobenzyloxy)aniline

CAS: 202197-26-0

Formula: C₁₃H₁₁ClFNO

Purity: >98.0%(GC)(T)

Color and Shape: White to Gray to Red powder to crystal

Molecular weight: 251.69

Ref: 3B-C2874

3-Chloro-4-[(3-fluorobenzyl)oxy]aniline

CAS: 202197-26-0

3-Chloro-4-[(3-fluorobenzyl)oxy]aniline

Purity: 98%

Color and Shape: Grey Solid

Molecular weight: 251.68g/mol

Ref: 54-PC5666

3-Chloro-4-(3-fluorobenzyloxy)aniline

CAS: 202197-26-0

Applications 3-Chloro-4-(3-fluorobenzyloxy)aniline is an intermediate in the synthesis of Lapatinib (L175800).
References Petrov, K., et al.: Bioorg. Med. Chem. Lett., 16, 4686 (2006),

Formula: C₁₃H₁₁ClFNO

Color and Shape: Brown

Molecular weight: 251.68

Ref: TR-C377650

Lapatinib Impurity 19

CAS: 202197-26-0

Formula: C₁₃H₁₁ClFNO

Molecular weight: 251.69

Ref: ST-EA-CP-L46017

3-Chloro-4-[(3-fluorobenzyl)oxy]aniline

CAS: 202197-26-0

Formula: C₁₃H₁₁ClFNO

Purity: 97%

Color and Shape: Brown powder

Molecular weight: 251.69

Ref: 10-F064714

3-Chloro-4-(3-fluorobenzyloxy)aniline

CAS: 202197-26-0

3-Chloro-4-(3-fluorobenzyloxy)aniline is a potent inhibitor of the epidermal growth factor receptor (EGFR), which is a tyrosine kinase that plays an important role in the initiation and progression of cancer. The compound has been shown to inhibit the proliferation of human cancer cell lines, such as breast cancer and prostate cancer, by blocking EGFR signaling. 3-Chloro-4-(3-fluorobenzyloxy)aniline also inhibits the activity of other kinases, such as lapatinib and 2-amino-4-fluorobenzoic acid. This inhibition may be due to its ability to bind to the ATP binding site on these enzymes.

Formula: C₁₃H₁₁ClFNO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 251.68 g/mol

Ref: 3D-FC37254