CAS 202463-68-1

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide

Description:

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide, with CAS number 202463-68-1, is a synthetic organic compound characterized by its complex structure, which includes a pyrazole core substituted with various functional groups. This compound features dichlorophenyl and iodophenyl moieties, contributing to its potential biological activity. The presence of a morpholine group enhances its solubility and may influence its pharmacokinetic properties. Typically, compounds of this nature are investigated for their potential as pharmaceuticals, particularly in the context of anti-inflammatory or anticancer activities. The specific arrangement of substituents can significantly affect the compound's reactivity, stability, and interaction with biological targets. Additionally, the presence of halogen atoms (chlorine and iodine) often plays a crucial role in modulating the lipophilicity and overall biological profile of the molecule. As with many synthetic compounds, safety and toxicity assessments are essential for understanding its suitability for therapeutic applications.

Formula: C₂₁H₁₉Cl₂IN₄O₂

InChI: InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)

InChI key: InChIKey=AJFFBPZYXRNAIC-UHFFFAOYSA-N

SMILES: CC1=C(N(N=C1C(NN2CCOCC2)=O)C3=C(Cl)C=C(Cl)C=C3)C4=CC=C(I)C=C4

Synonyms:

• 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
• 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide
• 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-
• Am 281
• 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(morpholin-4-yl)-1H-pyrazole-3-carboxamide
• AM281;AM-281
• CS-1127
• AM-281 ,99%
• 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide AM 281

1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-

CAS: 202463-68-1

Formula: C₂₁H₁₉Cl₂IN₄O₂

Purity: 98%

Molecular weight: 557.2116

Ref: IN-DA00288Q

AM281

CAS: 202463-68-1

Formula: C₂₁H₁₉Cl₂IN₄O₂

Molecular weight: 557.21

Ref: 7W-GK0466

AM281

CAS: 202463-68-1

AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.

Formula: C₂₁H₁₉Cl₂IN₄O₂

Purity: 98.6% - >99.99%

Color and Shape: White To Off-White Solid

Molecular weight: 557.21

Ref: TM-T2264

AM 281

Controlled Product

CAS: 202463-68-1

Formula: C₂₁H₁₉Cl₂IN₄O₂

Color and Shape: Neat

Molecular weight: 557.21

Ref: TR-A575845

AM 281

Controlled Product

CAS: 202463-68-1

AM281 is a cannabinoid receptor antagonist that binds to the CB1 cannabinoid receptor and blocks the effect of cannabinoids. AM281 has been shown to reduce the number of bowel disease-related symptoms in mice by reversing the up-regulation of toll-like receptors (TLRs) in the colon. AM281 also reduces inflammation and injury by inhibiting DPP-IV, an enzyme that destroys insulin, which leads to a synergistic effect on neurons in rats. AM281 has been shown to have a synergistic effect with DPP-IV inhibitors, leading to an increase in neuronal activity and improved memory retention. It is used for brain injury research, as it blocks the effects of cannabinoids on hippocampal neurons.

Formula: C₂₁H₁₉Cl₂IN₄O₂

Purity: Min. 95%

Molecular weight: 557.21 g/mol

Ref: 3D-CIA46368