CAS 203849-91-6

MonoMethyl Dolastatin 10

Description:

MonoMethyl Dolastatin 10, with the CAS number 203849-91-6, is a synthetic derivative of dolastatin, a peptide originally isolated from the sea hare *Dolabella auricularia*. This compound exhibits potent antitumor activity and is primarily studied for its potential in cancer therapy. Its structure features a cyclic peptide backbone, which contributes to its biological activity by interfering with microtubule dynamics, thereby inhibiting cell division. MonoMethyl Dolastatin 10 is characterized by its ability to selectively target cancer cells while minimizing effects on normal cells, making it a candidate for targeted cancer treatments. The compound is typically administered in a controlled manner due to its high potency and potential side effects. Research continues to explore its efficacy, optimal dosing regimens, and mechanisms of action, as well as its potential combination with other therapeutic agents to enhance anticancer effects. Overall, MonoMethyl Dolastatin 10 represents a significant advancement in the development of novel chemotherapeutic agents.

Formula: C₄₁H₆₆N₆O₆S

Synonyms:

• MMAD (Demethyldolastatin 10
• MonoMethylauristatin D
• N-Methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
• CS-1368
• DEMETHYLDOLASTATIN 10; MONOMETHYLAURISTATIN D; MONOMETHYL DOLASTATIN 10
• L-Valinamide, N-methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
• DeMethyldolastatin 10
• Demethyldolastatin (MMAD)
• EOS-60620
• MMAD
• (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

Monomethyl Dolastatin 10

CAS: 203849-91-6

Formula: C₁₆H₂₂N₂O₆S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 402.4857

Ref: IN-DA00294Z

MMAD

CAS: 203849-91-6

MMAD

Purity: ≥98%

Molecular weight: 771.06g/mol

Ref: 54-BUP11581

MMAD

CAS: 203849-91-6

MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).

Formula: C₄₁H₆₆N₆O₆S

Purity: 99.25% - 99.91%

Color and Shape: Solid

Molecular weight: 771.06

Ref: TM-T4677

MonoMe Auristatin D

CAS: 203849-91-6

MonoMe Auristatin D is a synthetic compound, which is a potent cytotoxic agent derived from modifications of natural dolastatin 10. It is synthesized to enhance its therapeutic potential and stability, leveraging the structural design of natural marine peptides. MonoMe Auristatin D works by inhibiting cell division through binding to tubulin, thus disrupting the microtubule network essential for cell mitosis. This mechanism interferes with cell replication, leading to apoptosis in rapidly dividing tumor cells.

Formula: C₄₁H₆₆N₆O₆S

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 771.06 g/mol

Ref: 3D-DIA84991

MMAD

CAS: 203849-91-6

Purity: 98%

Molecular weight: 771.08

Ref: 10-F862119

Monomethyl Auristatin D (MMAD)-d8

Controlled Product

CAS: 203849-91-6

Formula: C₄₁D₈H₅₈N₆O₆S

Color and Shape: Neat

Molecular weight: 779.114

Ref: TR-M425406