CAS 204005-46-9

Semaxinib

Description:

Semaxinib, with the CAS number 204005-46-9, is a small molecule that functions primarily as a selective inhibitor of certain kinases, particularly those involved in cancer cell proliferation and survival. It is characterized by its ability to interfere with specific signaling pathways, making it a candidate for targeted cancer therapies. Semaxinib exhibits a favorable pharmacokinetic profile, which includes good oral bioavailability and the potential for effective tissue distribution. The compound has been studied for its efficacy in various preclinical models, demonstrating the ability to inhibit tumor growth and metastasis. Additionally, Semaxinib's mechanism of action involves the modulation of cellular processes such as apoptosis and angiogenesis, which are critical in cancer progression. Its development is part of a broader effort to create more effective and less toxic cancer treatments, focusing on precision medicine approaches. As research continues, the full therapeutic potential and safety profile of Semaxinib are being evaluated in clinical settings.

Formula: C₁₅H₁₄N₂O

InChI: InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)

InChI key: InChIKey=WUWDLXZGHZSWQZ-UHFFFAOYSA-N

SMILES: C(=C1C=2C(NC1=O)=CC=CC2)C=3NC(C)=CC3C

Synonyms:

• (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
• (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
• (Z)-3-(3,5-Dimethylpyrrol-2-ylmethylene)indolin-2-one
• 2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-
• 3-((2,4-Dimethylpyrrol-5-YL)METHYLIDENYL)-2-indolonone
• 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one
• 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
• 3-[(3,5-Dimethylpyrrol-2-yl)methylene]indolin-2-one
• Nsc-696819
• Semaxanib
• Semaxinib
• Semoxind
• Su-5416
• Sugen 5416
• Tsu-16

2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-

CAS: 204005-46-9

Formula: C₁₅H₁₄N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 238.2845

Ref: IN-DA00298W

SU 5416

CAS: 204005-46-9

Formula: C₁₅H₁₄N₂O

Molecular weight: 238.28

Ref: 7W-GK8247

Semaxinib

CAS: 204005-46-9

Semaxinib

Purity: ≥98%

Molecular weight: 238.28g/mol

Ref: 54-BUP13510

SU 5416

CAS: 204005-46-9

Formula: C₁₅H₁₄N₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Yellow to Orange powder to crystal

Molecular weight: 238.29

Ref: 3B-E1494

Semaxinib

CAS: 204005-46-9

Semaxinib (SU5416): potent VEGFR2 inhibitor, 20x more selective over PDGFRβ, not active on InsR/EGFR/FGFR, blocks ATP on VEGFR2, may reduce tumor vessels.

Formula: C₁₅H₁₄N₂O

Purity: 99.84%

Color and Shape: Yellow To Yellow Orange

Molecular weight: 238.28

Ref: TM-T2064

SU 5416

CAS: 204005-46-9

Inhibitor of Flk-1/KDR receptor tyrosine kinases, a vascular endothelial growth factor receptor (VEGF) receptor expressed on precursor and mature forms of endothelial cells. SU 5416 also inhibits other tyrosine kinases, including c-KIT and FLT-3. Has therapeutic potential as an anti-angiogenic agent for the treatment of cancer.

Formula: C₁₅H₁₄N₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 238.28 g/mol

Ref: 3D-FD65177

SU 5416

Controlled Product

CAS: 204005-46-9

Applications SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into tumor tissues.
References Mizuno, S. et al.: Am. J. Respir. Cell. Mol. Biol., 47, 679 (2012)); Yoshizawa, Y. et al.: Mol. Pharm., 9, 3486 (2012);

Formula: C₁₅H₁₄N₂O

Color and Shape: Neat

Molecular weight: 238.28

Ref: TR-S688030