CAS 204005-46-9: Semaxinib

Description: Semaxinib, with the CAS number 204005-46-9, is a small molecule that functions primarily as a selective inhibitor of certain kinases, particularly those involved in cancer cell proliferation and survival. It is characterized by its ability to interfere with specific signaling pathways, making it a candidate for targeted cancer therapies. Semaxinib exhibits a favorable pharmacokinetic profile, which includes good oral bioavailability and the potential for effective tissue distribution. The compound has been studied for its efficacy in various preclinical models, demonstrating the ability to inhibit tumor growth and metastasis. Additionally, Semaxinib's mechanism of action involves the modulation of cellular processes such as apoptosis and angiogenesis, which are critical in cancer progression. Its development is part of a broader effort to create more effective and less toxic cancer treatments, focusing on precision medicine approaches. As research continues, the full therapeutic potential and safety profile of Semaxinib are being evaluated in clinical settings.

Formula: C₁₅H₁₄N₂O

InChI: InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)

InChI key: InChIKey=WUWDLXZGHZSWQZ-UHFFFAOYSA-N

SMILES: O=C1NC=2C=CC=CC2C1=CC=3NC(=CC3C)C

Synonyms:

• (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
• (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
• (Z)-3-(3,5-Dimethylpyrrol-2-ylmethylene)indolin-2-one
• 2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-
• 3-((2,4-Dimethylpyrrol-5-YL)METHYLIDENYL)-2-indolonone
• 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one
• 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
• 3-[(3,5-Dimethylpyrrol-2-yl)methylene]indolin-2-one
• Nsc-696819
• Semaxanib
• Semaxinib
• Semoxind
• Su-5416
• Sugen 5416
• Tsu-16
• VEGFR2 receptor tyrosine kinase III

2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-

CAS: 204005-46-9

• Formula: C₁₅H₁₄N₂O
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 238.2845

SU 5416

CAS: 204005-46-9

• Formula: C₁₅H₁₄N₂O
• Molecular weight: 238.28

SU 5416

CAS: 204005-46-9

• Formula: C₁₅H₁₄N₂O
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Yellow to Orange powder to crystal
• Molecular weight: 238.29

Semaxinib

CAS: 204005-46-9

Semaxinib (SU5416): potent VEGFR2 inhibitor, 20x more selective over PDGFRβ, not active on InsR/EGFR/FGFR, blocks …

• Formula: C₁₅H₁₄N₂O
• Purity: 99.84%
• Color and Shape: Yellow To Yellow Orange
• Molecular weight: 238.28

SU 5416

CAS: 204005-46-9

Inhibitor of Flk-1/KDR receptor tyrosine kinases, a vascular endothelial growth factor receptor (VEGF) receptor expressed …

• Formula: C₁₅H₁₄N₂O
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 238.28 g/mol

SU 5416

CAS: 204005-46-9

Applications SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe …

• Formula: C₁₅H₁₄N₂O
• Color and Shape: Neat
• Molecular weight: 238.28