CAS 2041073-22-5

Formula: C25H27FN6O4

InChI: InChI=1S/C25H27FN6O4/c1-14(2)36-16-5-6-18(26)17(10-16)19-12-29-23(27)22(30-19)24(33)31-20-11-28-8-7-21(20)32-9-3-4-15(13-32)25(34)35/h5-8,10-12,14-15H,3-4,9,13H2,1-2H3,(H2,27,29)(H,31,33)(H,34,35)/t15-/m1/s1

InChI key: UZIATSFXNVOVFE-OAHLLOKOSA-N

SMILES: CC(C)OC1=CC(=C(C=C1)F)C2=CN=C(C(=N2)C(=O)NC3=C(C=CN=C3)N4CCC[C@H](C4)C(=O)O)N

GNF4877

CAS: 2041073-22-5

GNF4877

Formula: C₂₅H₂₇FN₆O₄

Purity: ≥98%

Molecular weight: 494.52

Ref: 54-BUP05325

GNF4877

CAS: 2041073-22-5

Formula: C₂₅H₂₇FN₆O₄

Purity: 99%

Molecular weight: 494.5181

Ref: IN-DA01N18O

GNF4877

CAS: 2041073-22-5

GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.

Formula: C₂₅H₂₇FN₆O₄

Purity: 98.68% - 99.51%

Color and Shape: Solid

Molecular weight: 494.5181

Ref: TM-T11447

GNF4877

CAS: 2041073-22-5

(R)-1-(3-(3-Amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylic acid

Formula: C₂₅H₂₇FN₆O₄

Purity: 99%

Molecular weight: 494.52

Ref: IN-DG01095077

GNF4877

CAS: 2041073-22-5

GNF4877 is an oral medication that has been shown to enhance the ability of insulin-producing cells, called β-cells, to produce and release insulin in response to glucose levels. This drug selectively inhibits the kinase activity of a growth factor receptor called "growth factor receptor β" (GRβ), which is found on the surface of cells. The inhibition of GRβ leads to increased production of a protein called "effector protein 1" (E1P1) in pancreatic β-cells. Increased E1P1 enhances glucose uptake and stimulates the production and release of insulin by β-cells, which can be used as an alternative treatment for diabetes mellitus type 2.

Formula: C₂₅H₂₇FN₆O₄

Purity: Min. 95%

Molecular weight: 494.5 g/mol

Ref: 3D-RGD07322