CAS 204326-43-2

8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one

Description:

8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one is a heterocyclic compound characterized by its complex structure, which includes both oxadiazole and benzoxazine moieties. This compound typically exhibits a high degree of stability due to the presence of multiple aromatic rings, which contribute to its rigidity and electronic properties. The bromine substituent at the 8-position enhances its reactivity, making it a useful intermediate in various chemical syntheses. It is often studied for its potential applications in pharmaceuticals, agrochemicals, and materials science due to its unique electronic and photophysical properties. The compound may also exhibit interesting biological activities, which are of interest in medicinal chemistry. Its solubility and stability in different solvents can vary, influencing its practical applications. As with many heterocycles, the presence of nitrogen and oxygen atoms in the ring structure can impart specific chemical reactivity, making it a subject of interest for further research in organic synthesis and drug development.

Formula: C₉H₅BrN₂O₃

InChI: InChI=1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2

InChI key: InChIKey=MUDRLQRJCGJJTB-UHFFFAOYSA-N

SMILES: O=C1N2C=3C(OCC2=NO1)=CC=C(Br)C3

Synonyms:

• 1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]benzoxazin-1-one, 8-bromo-
• 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)ben(b)(1,4)oxazin-1-one
• 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
• Ns 2028
• 8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one

NS-2028

CAS: 204326-43-2

NS-2028 is a selective sGC inhibitor, affecting both basal and NO-activated activities; used in nitric oxide research.

Formula: C₉H₅BrN₂O₃

Purity: 99.44%

Color and Shape: A Crystalline Solid

Molecular weight: 269.05

Ref: TM-T16344

1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]benzoxazin-1-one, 8-bromo-

CAS: 204326-43-2

Formula: C₉H₅BrN₂O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 269.0516

Ref: IN-DA0029G2

NS-2028

CAS: 204326-43-2

NS-2028

Purity: ≥98%

Molecular weight: 269.05g/mol

Ref: 54-BUP09480

NS 2028

CAS: 204326-43-2

Formula: C₉H₅BrN₂O₃

Molecular weight: 269.05

Ref: 7W-GK3622

NS-2028

Controlled Product

CAS: 204326-43-2

Applications NS-2028 potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). NS-2028 blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA. NS-2028 inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).
References Olesen, et al.: Br. J. Pharmacol., 123, 299 (1998), von Wantoch Rekowski, et al.: Bioorg. Med. Chem. 18, 1288 (2010),

Formula: C₉H₅BrN₂O₃

Color and Shape: Neat

Molecular weight: 269.05

Ref: TR-N900200