CAS 2051527-54-7

Formula: C61H88N16O22S2

InChI: InChI=1S/C61H88N16O22S2/c1-61(40-8-12-43(78)13-9-40,41-10-14-44(79)15-11-41)17-16-49(81)66-46(57(92)93)33-51(83)67-47(58(94)95)34-50(82)65-45(6-2-3-20-77-35-42(69-72-77)5-4-7-48(80)68-59-70-71-60(100-59)101(62,96)97)56(91)64-19-30-99-32-31-98-29-18-63-52(84)36-73-21-23-74(37-53(85)86)25-27-76(39-55(89)90)28-26-75(24-22-73)38-54(87)88/h8-15,35,45-47,78-79H,2-7,16-34,36-39H2,1H3,(H,63,84)(H,64,91)(H,65,82)(H,66,81)(H,67,83)(H,85,86)(H,87,88)(H,89,90)(H,92,93)(H,94,95)(H2,62,96,97)(H,68,70,80)/t45-,46-,47-/m0/s1

InChI key: DMAXCXQYACQFKS-OLCJBLMYSA-N

SMILES: CC(CCC(=O)N[C@@H](CC(=O)N[C@@H](CC(=O)N[C@@H](CCCCN1C=C(N=N1)CCCC(=O)NC2=NN=C(S2)S(=O)(=O)N)C(=O)NCCOCCOCCNC(=O)CN3CCN(CCN(CCN(CC3)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)O)C(=O)O)(C4=CC=C(C=C4)O)C5=CC=C(C=C5)O

DOTA-XYIMSR-01

CAS: 2051527-54-7

DOTA-XYIMSR-01 is a molecular probe targeting CAIX, capable of being labeled with 177Lu for the treatment and localization of malignant gliomas. The uptake of [177Lu]Lu-XYIMSR-01 in U87MG tumors is 6.19% injected dose per gram (% ID/g), with a tumor-to-muscle uptake ratio of 20.14. In an orthotopic glioma model, co-administration with temozolomide significantly enhances survival rates and inhibits tumor growth in mice. DOTA-XYIMSR-01 shows potential for research in the field of cancer treatment.

Formula: C₆₁H₈₈N₁₆O₂₂S₂

Color and Shape: Solid

Molecular weight: 1461.57

Ref: TM-T206524