CAS 205393-22-2
:Bortezomib-pinanediol
Description:
Bortezomib-pinanediol, identified by its CAS number 205393-22-2, is a synthetic compound primarily known for its role as a proteasome inhibitor. It is a derivative of bortezomib, which is used in the treatment of multiple myeloma and certain types of lymphoma. The compound exhibits a complex structure that includes a boronic acid moiety, which is crucial for its mechanism of action, as it binds to the active site of the proteasome, disrupting protein degradation pathways. This inhibition leads to the accumulation of pro-apoptotic factors and cell cycle regulators, ultimately inducing apoptosis in cancer cells. Bortezomib-pinanediol may also possess unique pharmacokinetic properties due to the pinanediol component, potentially influencing its solubility and bioavailability. As with many pharmaceutical compounds, its efficacy and safety profile are subject to extensive research and clinical evaluation. Overall, bortezomib-pinanediol represents a significant advancement in targeted cancer therapies, contributing to the ongoing development of proteasome inhibitors in oncology.
Formula:C29H39BN4O4
Synonyms:- Bortezomib pinanediol ester
- N-[(1S)-2-[[(1R)-1-[(3As,4S,6S,7Ar)-Hexahydro-3A,5,5-Trimethyl-4,6-Methano-1,3,2-Benzodioxaborol-2-Yl]-3-Methylbutyl]Amino]-2-Oxo-1-(Phenylmethyl)Ethyl]-2-Pyrazinecarboxamide
- N-[(1S)-1-Benzyl-2-({(1R)-3-Methyl-1-[(1S,2S,6R,8S)-2,9,9-Trimethyl-3,5-Dioxa-4-Boratricyclo[6.1.1.0~2,6~]Dec-4-Yl]Butyl}Amino)-2-Oxoethyl]-2-Pyrazinecarboxamide
- Bortezomib Intermediates Iii
- Bortezomib Intermediate III
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Found 9 products.
Bortezomib-pinanediol
CAS:Formula:C29H39BN4O4Purity:98%Color and Shape:SolidMolecular weight:518.4554Bortezomib-pinanediol
CAS:Bortezomib-pinanediol is a proteasome inhibitor. is a prodrug of Bortezomib.Formula:C29H39BN4O4Purity:97.5%Color and Shape:SolidMolecular weight:518.46Bortezomib-pinanediol
CAS:N-((S)-1-(((R)-3-Methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamideFormula:C29H39BN4O4Purity:98%Molecular weight:518.46(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate
CAS:(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate is a boronic acid derivative that has been shown to have an antiproliferative effect on cancer cells. It is a biodegradable, water soluble drug with a low toxicity profile. The maximum tolerated dose has been established in vivo studies and it can be used as an imaging agent for diagnosis. (1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate may be used to treat cancers such as breast cancer or leukemia. This drug targets the proteasome and inhibits its activity by binding to the active site of the 20sFormula:C29H39BN4O4Purity:Min. 95%Color and Shape:SolidMolecular weight:518.46 g/mol(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate (>90%)
CAS:Controlled ProductImpurity Bortezomib Pinanediol Impurity
Applications Intermediate in the preparation of Bortezomib (B675700), a dipeptidyl boronate proteasome inhibitor.
References Zhu, Y., et al.: Bioorg. Med. Chem., 14, 1483 (2006), Dorsey, B., et al.: J. Med. Chem., 51, 1068 (2008), Zhu, Y., et al.: Eur. J .Med. Chem., 44, 1486 (2009),Formula:C29H39BN4O4Purity:>90%Color and Shape:NeatMolecular weight:518.46
