CAS 205640-91-1

Orexin B (human)

Description:

Orexin B, also known as hypocretin-2, is a neuropeptide that plays a crucial role in regulating arousal, wakefulness, and appetite in humans. It is produced in the hypothalamus and is part of the orexin system, which includes orexin A and orexin B. Orexin B is characterized by its specific amino acid sequence and structure, which allows it to bind to orexin receptors (OX1R and OX2R) in the brain, influencing various physiological processes. This peptide is involved in the modulation of energy balance and has been implicated in sleep disorders, particularly narcolepsy. Orexin B's biological activity is influenced by its stability and interactions with other neuropeptides and neurotransmitters. The CAS number 205640-91-1 uniquely identifies this compound, facilitating its recognition in scientific literature and databases. Overall, orexin B is a significant player in neurobiology, with potential implications for therapeutic interventions in sleep-related and metabolic disorders.

Formula: C₁₂₃H₂₁₂N₄₄O₃₅S

Synonyms:

• L-Methioninamide,L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leu
• H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
• Orexin B(human)
• Hypocretin-2 (huMan)
• L-Methioninamide, L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-
• Orexin B (human), ≥98% (HPLC)
• REF DUPL: Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
• Orexin B (human) (trifluoroacetate salt)
• OREXIN B HUMAN ≥98%
• RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2
• OREXIN B (HUMAN) USP/EP/BP
• HYPOCRETIN-2, HUMAN
• PubChem ID: 90479794
• OREXINS OREXIN B HUMAN
• Human orexin B
• ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2

Orexin B (human)

CAS: 205640-91-1

Like orexin A, orexin B (OXB) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of OXB to rats stimulated food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX₁ receptor is significantly lower (IC₅₀ = 240 nM) than that of orexin A. Binding affinities for the OX₂ receptor are similar for orexin A and B (IC₅₀ = 38 nM and 36 nM, respectively, for displacement of radiolabeled orexin A bound to the receptor).

Formula: C₁₂₃H₂₁₂N₄₄O₃₅S

Purity: 96.3%

Color and Shape: White

Molecular weight: 2899.38

Ref: 01-4028263

Orexin B, human

CAS: 205640-91-1

Orexin B, human agonizes Orexin receptors (OX1 Ki=420 nM, OX2 Ki=36 nM), promotes feeding in rats, and is a neuropeptide.

Formula: C₁₂₃H₂₁₂N₄₄O₃₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 2899.34

Ref: TM-TP1139

Orexin B (human)

CAS: 205640-91-1

Orexin B (human)

Ref: 54-BIBA1033

Orexin-B (Human)

CAS: 205640-91-1

Orexin B, also known as hypocretin-2, is a neuropeptide that is produced by a small group of neurons in the hypothalamus, a region of the brain that plays a critical role in regulating various physiological functions, including sleep, appetite, and energy balance.
Orexin B plays a role in promoting wakefulness and arousal and studies have shown that disruptions in the orexin system are associated with various sleep disorders, including narcolepsy and insomnia. In addition, orexin B has been shown to be involved in the regulation of appetite and energy metabolism, and is being explored as a potential target for the treatment of obesity and other metabolic disorders. Therefore, orexin B is an important neuropeptide and is an active area of research in neuroscience and medicine. This product is available as a 0.1mg vial

Formula: C₁₂₃H₂₁₂N₄₄O₃₅S

Purity: Min. 95%

Molecular weight: 2,899.3 g/mol

Ref: 3D-POR-4348-S

Orexin B (human) trifluoroacetate salt

CAS: 205640-91-1

Orexin B (human) trifluoroacetate salt H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln -Ala -Ser -Gly -Asn -His -Ala -Ala -Gly -Ile -Leu -Thr
Met –NH2 trifluoroacetate salt is an amino acid sequence that is found in the human body. It is a polypeptide that regulates arousal, wakefulness, and appetite. Orexin B (human) trifluoroacetate salt H Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met NH2 trifluoroacetate salt promotes apoptosis by binding to c

Formula: C₁₂₃H₂₁₂N₄₄O₃₅S

Purity: Min. 95%

Molecular weight: 2,899.34 g/mol

Ref: 3D-FO109202