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CAS 2068-78-2

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Vincristine sulfate

Description:
Vincristine sulfate is a potent alkaloid derived from the periwinkle plant, Vinca rosea, and is primarily used in chemotherapy for treating various types of cancer, including leukemia and lymphoma. It functions as a vinca alkaloid, inhibiting microtubule formation during cell division, which effectively disrupts mitosis and halts cancer cell proliferation. The compound appears as a white to off-white powder and is soluble in water, making it suitable for intravenous administration. Vincristine sulfate has a molecular formula that reflects its complex structure, characterized by multiple ring systems and functional groups. Its pharmacokinetics involve hepatic metabolism, and it is known for its neurotoxic side effects, which can lead to peripheral neuropathy. Additionally, it has a narrow therapeutic index, necessitating careful dosing and monitoring. Due to its mechanism of action and side effect profile, vincristine sulfate is often part of combination chemotherapy regimens, enhancing the overall efficacy of cancer treatment while minimizing resistance development.
Formula:C46H56N4O10·H2O4S
InChI:InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
InChI key:InChIKey=AQTQHPDCURKLKT-PNYVAJAMSA-N
SMILES:S(=O)(=O)(O)O.C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C=O)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)CC[N@@]9C[C@](C6)(C[C@](CC)(O)C9)[H])[H])CCN3CC=C2)[H]
Synonyms:
  • (2Alpha,2'Beta,3Alpha,4Alpha,5Beta,19Beta)-22-Oxovincaleukoblastine
  • (2Alpha,2'Beta,3Alpha,4Alpha,5Beta,19Beta)-22-Oxovincaleukoblastine Sulfate
  • (2Alpha,2'Beta,3Alpha,4Alpha,5Beta,19Beta)-22-Oxovincaleukoblastine Sulfate (1:1)
  • (2Alpha,3Alpha,4Alpha,5Beta,19Beta)-22-Oxovincaleukoblastine Sulfate
  • 22-Oxovincaleukoblastine sulfate salt
  • Kyocristine
  • Leurocristine sulfate
  • Leurocristine sulfate salt
  • Leurocristine, sulfate (1:1) (salt)
  • Lilly 37231
  • See more synonyms
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