CAS 2068-78-2

Vincristine sulfate

Description:

Vincristine sulfate is a potent alkaloid derived from the periwinkle plant, Vinca rosea, and is primarily used in chemotherapy for treating various types of cancer, including leukemia and lymphoma. It functions as a vinca alkaloid, inhibiting microtubule formation during cell division, which effectively disrupts mitosis and halts cancer cell proliferation. The compound appears as a white to off-white powder and is soluble in water, making it suitable for intravenous administration. Vincristine sulfate has a molecular formula that reflects its complex structure, characterized by multiple ring systems and functional groups. Its pharmacokinetics involve hepatic metabolism, and it is known for its neurotoxic side effects, which can lead to peripheral neuropathy. Additionally, it has a narrow therapeutic index, necessitating careful dosing and monitoring. Due to its mechanism of action and side effect profile, vincristine sulfate is often part of combination chemotherapy regimens, enhancing the overall efficacy of cancer treatment while minimizing resistance development.

Formula: C₄₆H₅₆N₄O₁₀·H₂O₄S

InChI: InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1

InChI key: InChIKey=AQTQHPDCURKLKT-PNYVAJAMSA-N

SMILES: S(=O)(=O)(O)O.C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C=O)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)CC[N@@]9C[C@](C6)(C[C@](CC)(O)C9)[H])[H])CCN3CC=C2)[H]

Synonyms:

• (2Alpha,2'Beta,3Alpha,4Alpha,5Beta,19Beta)-22-Oxovincaleukoblastine
• (2Alpha,2'Beta,3Alpha,4Alpha,5Beta,19Beta)-22-Oxovincaleukoblastine Sulfate
• (2Alpha,2'Beta,3Alpha,4Alpha,5Beta,19Beta)-22-Oxovincaleukoblastine Sulfate (1:1)
• (2Alpha,3Alpha,4Alpha,5Beta,19Beta)-22-Oxovincaleukoblastine Sulfate
• 22-Oxovincaleukoblastine sulfate salt
• Kyocristine
• Leurocristine sulfate
• Leurocristine sulfate salt
• Leurocristine, sulfate (1:1) (salt)
• Lilly 37231
• Marqibo
• NSC 67574
• Novopharm
• Oncovin
• Onkovin
• VCR sulfate
• Vincaleukoblastine, 22-oxo-, sulfate (1:1)
• Vincaleukoblastine, 22-oxo-, sulfate (1:1) (salt)
• Vincasar PFS
• Vincristine Sulfate, Apocynaceae sp.
• Vincristine Sulphate
• Vincristine hydrogen sulfate
• Vincristine sulfate liposome injection
• Vincristine sulfate salt

Vincristine Sulfate

CAS: 2068-78-2

Formula: C₄₆H₅₆N₄O₁₀·H₂SO₄

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystaline

Molecular weight: 923.04

Ref: 3B-V0129

Vincristine sulfate, 97+%

CAS: 2068-78-2

An anti-tumor alkaloid used in cancer research

Formula: C₄₆H₅₈N₄O₁₄S

Purity: 97+%

Molecular weight: 923.04

Ref: 02-J60907

VINCRISTINE SULFATE CRS

CAS: 2068-78-2

VINCRISTINE SULFATE CRS

Formula: C₄₆H₅₈N₄O₁₄S

Color and Shape: Added Modified

Molecular weight: 923.0361

Ref: 41-V0400000

Vincristine Sulfate

CAS: 2068-78-2

Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi

Formula: C₄₆H₅₆N₄O₁₀·H₂SO₄

Color and Shape: White Off-White Light Yellow Crystalline Powder

Molecular weight: 824.39964

Ref: 45-1714007

Vincristine sulfate

CAS: 2068-78-2

Vincristine sulfate is a natural alkaloid. Vincristine sulfate is used as a microtubule destabilizer for the study of tumors. Cost-effective, quality assurance.

Formula: C₄₆H₅₈N₄O₁₄S

Purity: 98% - 99.94%

Color and Shape: White Crystalline Powder

Molecular weight: 923.04

Ref: TM-T1270

Vincristine (sulfate)

CAS: 2068-78-2

Formula: C₄₆H₅₈N₄O₁₄S

Purity: %

Color and Shape: Solid

Molecular weight: 923.0361

Ref: IN-DA002IP8

Vincristine, sulphate salt

CAS: 2068-78-2

Vincristine, sulphate salt

Formula: C₄₆H₅₆N₄O₁₀·H₂SO₄

Purity: 99.66% (lc-ms) (Typical Value in Batch COA)

Color and Shape: White Solid

Molecular weight: 923.03612

Ref: 54-BIFK0048

Vincristine sulfate

CAS: 2068-78-2

Vincristine sulfate

Formula: C₄₆H₅₈N₄O₁₄S

Purity: ≥98%

Molecular weight: 923.04

Ref: 54-BUP00090

Vincristine sulfate

CAS: 2068-78-2

Formula: C₄₆H₅₈N₄O₁₄S

Purity: ≥ 98.0%

Color and Shape: White to light yellow powder

Molecular weight: 923.04

Ref: 7W-GA1776

Vincristine Sulfate

CAS: 2068-78-2

Formula: C₄₆H₅₈N₄O₁₄S

Purity: 95%~99%

Molecular weight: 923.044

Ref: BP-BP1440

Vincristine Sulfate

CAS: 2068-78-2

Formula: C₄₆H₅₆N₄O₁₀H₂SO₄

Molecular weight: 825.0 : 98.1

Ref: ST-EA-CP-V34001

Vincristine Sulfate (10 mg/mL in DMSO)

CAS: 2068-78-2

Formula: C₄₆H₅₆N₄O₁₀·H₂O₄S

Ref: TR-KIT5377-1ML

Vincristine Sulfate

Controlled Product

CAS: 2068-78-2

Formula: C₄₆H₅₆N₄O₁₀·H₂O₄S

Color and Shape: Neat

Molecular weight: 923.04

Ref: TR-V314250

Vincristine sulfate

Controlled Product

CAS: 2068-78-2

Inhibits assembly of mitotic spindle; depolymerizes microtubules; anti-cancer

Formula: C₄₆H₅₈N₄O₁₄S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 923.04 g/mol

Ref: 3D-FV28696

Vincristine-d6 xSulfate

Controlled Product

CAS: 2068-78-2

Formula: C₄₆H₅₀D₆N₄O₁₀H₂O₄S

Color and Shape: Neat

Molecular weight: 830.99

Ref: TR-V314254

Vincristine-d9 Sulfate

Controlled Product

CAS: 2068-78-2

Applications Vincristine-d9 Sulfate, is an Labeled analogue of Vincristine Sulfate (V314250), which is an antitumor alkaloid isolated from Vinca rosea Linn. It is also an antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Burns, J.H., et al.: Anal. Profiles Drug Subs., 1, 463 (1972), Owellen, D., et al.: J. Med. Chem., 15, 894 (1972),

Formula: C₄₆D₉H₄₇N₄O₁₀·H₂SO₄

Color and Shape: Neat

Molecular weight: 932.092

Ref: TR-V314251

Vincristine Sulfate (10 mg/mL in DMSO)

CAS: 2068-78-2

Formula: C₄₆H₅₆N₄O₁₀·H₂O₄S

Color and Shape: Single Solution

Molecular weight: 923.04

Ref: TR-KIT5377

Vincristine Sulfate (1mg/mL in DMSO)

CAS: 2068-78-2

Formula: C₄₆H₅₆N₄O₁₀·H₂O₄S

Ref: TR-KIT4166-1ML

Vincristine Sulfate (1 mg/mL in DMSO)

CAS: 2068-78-2

Formula: C₄₆H₅₆N₄O₁₀·H₂O₄S

Color and Shape: Kit

Molecular weight: 923.04

Ref: TR-KIT4166

Vincristine Sulfate (Assay) (DISCONTINUED)

CAS: 2068-78-2

Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoi

Formula: C₄₆H₅₆N₄O₁₀·H₂SO₄

Color and Shape: Powder

Molecular weight: 922.36702

Ref: 45-1714018