CAS 20736-09-8

saikosaponin a

Description:

Saikosaponin A is a triterpenoid saponin primarily derived from the roots of the plant Bupleurum falcatum, which is commonly used in traditional medicine. It is characterized by its complex structure, featuring a steroid-like backbone with multiple sugar moieties attached, which contributes to its biological activity. Saikosaponin A exhibits a range of pharmacological properties, including anti-inflammatory, hepatoprotective, and immunomodulatory effects. It has been studied for its potential therapeutic applications in various conditions, including liver diseases and cancer. The compound is known to interact with cell membranes and can influence cellular signaling pathways, which may underlie its diverse biological effects. Additionally, saikosaponin A has shown potential in enhancing the efficacy of certain chemotherapeutic agents. However, its bioavailability and metabolism in the human body are areas of ongoing research, as they can significantly affect its therapeutic potential. Overall, saikosaponin A represents a promising natural product with significant pharmacological interest.

Formula: C₄₂H₆₈O₁₃

InChI: InChI=1/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3/t21-,22-,23-,24-,25-,26+,27+,28+,29-,30+,31-,32-,33+,34+,35+,37+,38+,39-,40+,41-,42+/m1/s1

InChI key: InChIKey=KYWSCMDFVARMPN-FMIBPMOUSA-N

SMILES: C[C@]12[C@@]3(C4([C@@](CO3)([C@@H](O)C1)CCC(C)(C)C4)[H])C=C[C@]5([C@@]2(C)CC[C@@]6([C@]5(C)CC[C@H](O[C@H]7[C@H](O)[C@@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](O)[C@@H](C)O7)[C@]6(CO)C)[H])[H]

Synonyms:

• (3Beta,4Alpha,16Beta)-13,28-Epoxy-16,23-Dihydroxyolean-11-En-3-Yl-6-Deoxy-3-O-Beta-D-Glucopyranosyl-Beta-D-Galactopyranoside
• (3beta,13alpha,16beta,17alpha)-16,23-dihydroxy-13,28-epoxyolean-11-en-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl-beta-D-galactopyranoside
• (3β,4α,16β)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-galactopyranoside
• Oleanane, β-<span class="text-smallcaps">D</span>-galactopyranoside deriv.
• Salikosaponin A
• sailkosaponin A
• β-<span class="text-smallcaps">D</smallcap>-Galactopyranoside, (3β,4α,16β)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-<smallcap>D</span>-glucopyranosyl-
• (3β,4α,16β)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside
• β-D-Galactopyranoside, (3β,4α,16β)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-
• Oleanane, β-D-galactopyranoside deriv.
• Saikosaponin A
• Thesaikosaponin A
• [(3β,4R)-13,28-Epoxy-16β,23-dihydroxyolean-11-en-3-yl]3-O-(β-D-glucopyranosyl)-6-deoxy-β-D-galactopyranoside
• SAIKOSAPONIN A(RG)
• SABINYL ACETATE(RG)
• β-D-fucoside, (3β,4α,16β)-13,28-epoxy-16,23-
• Saikosaponin A, 98%, from Bupleurum chinense DC.
• SAILKOSAPONINS A
• dihydroxyolean-11-en-3-yl6-deoxy-3-O-β-D-
• [(4R)-13,28-Epoxy-16β,23-dihydroxyolean-11-en-3β-yl]3-O-(β-D-glucopyranosyl)-6-deoxy-β-D-galactopyranoside
• Saikosaponin a std.

Saikosaponin A

CAS: 20736-09-8

Formula: C₄₂H₆₈O₁₃

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 780.99

Ref: 3B-A3408

SAIKOSAPONIN A CRS

CAS: 20736-09-8

SAIKOSAPONIN A CRS

Ref: 41-Y0001932

Saikosaponin A

CAS: 20736-09-8

Saikosaponin A

Formula: C₄₂H₆₈O₁₃

Purity: ≥98%

Molecular weight: 780.98

Ref: 54-BUP02763

Saikosaponin A

CAS: 20736-09-8

Formula: C₄₂H₆₈O₁₃

Molecular weight: 780.98

Ref: 7W-GC0592

Saikosaponin A

CAS: 20736-09-8

Saikosaponin A (SSa), a main constituent of the Chinese herb Bupleurum chinense DC, has antiepileptic activity,could inhibit NMDA receptor current and persistent sodium current, and inhibit epileptiform discharges induced by 4AP in a dose-dependent manner.

Formula: C₄₂H₆₈O₁₃

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 780.993

Ref: BP-BP1238

Saikosaponin A (Standard)

CAS: 20736-09-8

Saikosaponin A (Standard) is a reference standard for research and analysis in studies involving Saikosaponin A. Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropathic pain in CCI rats by inhibiting the activation of p38 MAPK and NF-κB signaling pathways in spinal cord. It can inhibit NMDA receptor current and persistent sodium current, and inhibit the TNF-α level, the IL-1β production, and cysteine-aspartic acid protease (caspase)-1 activity.

Formula: C₄₂H₆₈O₁₃

Color and Shape: Solid

Molecular weight: 780.9815

Ref: TM-TMSM-0961

Saikosaponin A

CAS: 20736-09-8

Formula: C₄₂H₆₈O₁₃

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 780.9815

Ref: IN-DA002J0O

Saikosaponin A

Controlled Product

CAS: 20736-09-8

Stability Hygroscopic
Applications Saikosaponin A was shown to exhibit anti-inflammatory activities by suppressing activation of NF-kB signaling pathway.
References Wu, S.J., et al.: Am. J. Chin. Med., 38, 99 (2010); Wu. S.J., et al.: J. Med. Food., 11, 224 (2008); Yoon, S.S., et al.: Neurosci. Lett., 529, 97 (2012); Lu, C.N., et al.: Int. Immunopharmacol., 14, 121 (2012);

Formula: C₄₂H₆₈O₁₃

Color and Shape: Neat

Molecular weight: 780.98

Ref: TR-S083900

Saikosaponin A

CAS: 20736-09-8

Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-

Formula: C₄₂H₆₈O₁₃

Purity: 99.57% - 99.88%

Color and Shape: White Solid

Molecular weight: 780.9815

Ref: TM-T2768

Saikosaponin A

CAS: 20736-09-8

Natural glycoside

Formula: C₄₂H₆₈O₁₃

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 781

Ref: 5G-89526

Saikosaponin A

CAS: 20736-09-8

Saikosaponin A is a triterpene saponin, which is a bioactive compound extracted from the roots of the Bupleurum species, primarily Bupleurum falcatum. As a phytochemical, it interacts with cell membranes to exert its effects. Saikosaponin A is known to modulate inflammatory pathways by inhibiting the production of pro-inflammatory cytokines and influencing the NF-κB signaling pathway. Additionally, it can enhance immune responses by regulating T-cell proliferation and differentiation.

Formula: C₄₂H₆₈O₁₃

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 780.98 g/mol

Ref: 3D-OS09826

Saikosaponin a

CAS: 20736-09-8

Formula: C₄₂H₆₈O₁₃

Molecular weight: 781.0

Ref: BE-RMT10740