CAS: 208255-80-5 - γ-Secretase inhibitor IX

Formula: C₂₃H₂₆F₂N₂O₄

InChI: InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1

InChI key: InChIKey=DWJXYEABWRJFSP-XOBRGWDASA-N

SMILES: O=C(OC(C)(C)C)C(NC(=O)C(NC(=O)CC=1C=C(F)C=C(F)C1)C)C=2C=CC=CC2

Synonyms:

• An-37124
• DAPT (enzyme inhibitor)
• Dapt
• Glycine, N-[(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
• Glycine, N-[2-(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
• Gsi-Ix
• Ly-374973
• N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester
• N-[N-(3,5-Difluorophenacetyl)-<span class="text-smallcaps">L</span>-alanyl]-S-phenylglycine tert-butyl ester
• N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester
• tert-butyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)ethanoate
• γ-Secretase inhibitor IX
• Glycine, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
• Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

DAPT

CAS: 208255-80-5

• Formula: C₂₃H₂₆F₂N₂O₄
• Purity: >97.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 432.47

DAPT

CAS: 208255-80-5

DAPT is used in the study of β-amyloid formation. DAPT has been shown to inhibit …

• Formula: C₂₃H₂₆F₂N₂O₄
• Color and Shape: Solid, White
• Molecular weight: 432.47

Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

CAS: 208255-80-5

• Formula: C₂₃H₂₆F₂N₂O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 432.4603

DAPT

CAS: 208255-80-5

DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and …

• Formula: C₂₃H₂₆F₂N₂O₄
• Purity: 98.06% - 99.81%
• Color and Shape: White Solid
• Molecular weight: 432.46

DAPT

CAS: 208255-80-5

• Purity: 98+%
• Molecular weight: 432.46g/mol

DAPT

CAS: 208255-80-5

• Formula: C₂₃H₂₆F₂N₂O₄
• Purity: (NMR) ≥ 98.0%
• Color and Shape: White to off-white solid
• Molecular weight: 432.50

DAPT

CAS: 208255-80-5

Applications DAPT is a γ-secretase inhibitor which inhibits thegrowth of cancer cells and epethelial and …

• Formula: C₂₃H₂₆F₂N₂O₄
• Color and Shape: Off White Solid
• Molecular weight: 432.46

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu

CAS: 208255-80-5

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a secretase inhibitor that inhibits the enzyme that cleaves amyloid precursor protein (APP) …

• Formula: C₂₃H₂₆N₂O₄F₂
• Purity: Min. 95%
• Molecular weight: 432.47 g/mol

DAPT

CAS: 208255-80-5

Inhibitor of proteaseγ‐secretase, which allows to modulate of the activity of γ‐secretase substrates Notch, E-cadherin, …

• Formula: C₂₃H₂₆O₄N₂F₂
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 432.46 g/mol

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu

CAS: 208255-80-5

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a peptide that is an inhibitor of Protein interactions. It blocks the binding …

• Formula: C₂₃H₂₆N₂O₄F₂
• Purity: Min. 95%
• Molecular weight: 432.46 g/mol