CAS 208255-80-5: γ-Secretase inhibitor IX
Description:γ-Secretase inhibitor IX is a small molecule compound known for its role in inhibiting the γ-secretase complex, which is crucial in the processing of amyloid precursor protein (APP) and the production of amyloid-beta peptides. This inhibition is of particular interest in Alzheimer's disease research, as the accumulation of amyloid-beta is associated with neurodegeneration. The compound is characterized by its ability to selectively interfere with the enzymatic activity of γ-secretase, thereby modulating the signaling pathways involved in cell proliferation and differentiation. Its chemical structure typically includes specific functional groups that enhance its binding affinity to the active site of the γ-secretase complex. In laboratory settings, γ-secretase inhibitor IX is utilized in various assays to study the effects of γ-secretase inhibition on cellular processes and to explore potential therapeutic strategies for neurodegenerative diseases. As with many pharmacological agents, the compound's efficacy and safety profile are critical for its potential application in clinical settings.
Formula:C23H26F2N2O4
InChI:InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChI key:InChIKey=DWJXYEABWRJFSP-XOBRGWDASA-N
SMILES:O=C(OC(C)(C)C)C(NC(=O)C(NC(=O)CC=1C=C(F)C=C(F)C1)C)C=2C=CC=CC2
- Synonyms:
- An-37124
- DAPT (enzyme inhibitor)
- Dapt
- Glycine, N-[(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
- Glycine, N-[2-(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
- Gsi-Ix
- Ly-374973
- N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester
- N-[N-(3,5-Difluorophenacetyl)-<span class="text-smallcaps">L</span>-alanyl]-S-phenylglycine tert-butyl ester
- N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester
- See more synonyms
- tert-butyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)ethanoate
- γ-Secretase inhibitor IX
- Glycine, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
- Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
![Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-](https://static.cymitquimica.com/products/IN/thumb/DA002JLH.jpg)
