CAS 208255-80-5

γ-Secretase inhibitor IX

Description:

γ-Secretase inhibitor IX is a small molecule compound known for its role in inhibiting the γ-secretase complex, which is crucial in the processing of amyloid precursor protein (APP) and the production of amyloid-beta peptides. This inhibition is of particular interest in Alzheimer's disease research, as the accumulation of amyloid-beta is associated with neurodegeneration. The compound is characterized by its ability to selectively interfere with the enzymatic activity of γ-secretase, thereby modulating the signaling pathways involved in cell proliferation and differentiation. Its chemical structure typically includes specific functional groups that enhance its binding affinity to the active site of the γ-secretase complex. In laboratory settings, γ-secretase inhibitor IX is utilized in various assays to study the effects of γ-secretase inhibition on cellular processes and to explore potential therapeutic strategies for neurodegenerative diseases. As with many pharmacological agents, the compound's efficacy and safety profile are critical for its potential application in clinical settings.

Formula: C₂₃H₂₆F₂N₂O₄

InChI: InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1

InChI key: InChIKey=DWJXYEABWRJFSP-XOBRGWDASA-N

SMILES: [C@@H](NC([C@@H](NC(CC1=CC(F)=CC(F)=C1)=O)C)=O)(C(OC(C)(C)C)=O)C2=CC=CC=C2

Synonyms:

• An-37124
• DAPT (enzyme inhibitor)
• Dapt
• Glycine, N-[(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
• Glycine, N-[2-(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
• Gsi-Ix
• Ly-374973
• N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester
• N-[N-(3,5-Difluorophenacetyl)-<span class="text-smallcaps">L</span>-alanyl]-S-phenylglycine tert-butyl ester
• N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester
• tert-butyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)ethanoate
• γ-Secretase inhibitor IX
• Glycine, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

DAPT

CAS: 208255-80-5

Formula: C₂₃H₂₆F₂N₂O₄

Purity: >97.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 432.47

Ref: 3B-D4257

DAPT

CAS: 208255-80-5

A cell-permeable dipeptide that suppresses A production by blocking -secretase

Formula: C₂₃H₂₆F₂N₂O₄

Color and Shape: Solid, White

Molecular weight: 432.47

Ref: 02-J65864

Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

CAS: 208255-80-5

Formula: C₂₃H₂₆F₂N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 432.4603

Ref: IN-DA002JLH

DAPT

CAS: 208255-80-5

DAPT

Purity: ≥98%

Molecular weight: 432.46g/mol

Ref: 54-BUP15441

DAPT

CAS: 208255-80-5

DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active.

Formula: C₂₃H₂₆F₂N₂O₄

Purity: 98.06% - 99.81%

Color and Shape: White Solid

Molecular weight: 432.46

Ref: TM-T6202

DAPT

CAS: 208255-80-5

DAPT

Purity: 98%

Molecular weight: 432.46g/mol

Ref: 54-BISN0140

DAPT

CAS: 208255-80-5

Formula: C₂₃H₂₆F₂N₂O₄

Purity: (NMR) ≥ 98.0%

Color and Shape: White to off-white solid

Molecular weight: 432.50

Ref: 7W-GK0567

DAPT

CAS: 208255-80-5

Applications DAPT is a γ-secretase inhibitor which inhibits thegrowth of cancer cells and epethelial and mesenchymal transition (1,2).
References (1) Li, L. et al.: Oncol Lett. 7, 2160 (2014) (2) Wang, M. et al.: Int. J. Onc., 44, 1401 (2014)

Formula: C₂₃H₂₆F₂N₂O₄

Color and Shape: Off White Solid

Molecular weight: 432.46

Ref: TR-D193290

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu

CAS: 208255-80-5

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a secretase inhibitor that inhibits the enzyme that cleaves amyloid precursor protein (APP) to release beta-amyloid. It has been shown to prevent the formation of plaques in the brain and may be used to treat Alzheimer's disease. (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu has also been shown to inhibit the production of tumor necrosis factor alpha (TNFα), which is involved in inflammation and carcinogenesis. The drug has been shown to reduce myocardial infarct size by preventing cardiac cell death and reducing inflammation following a heart attack. It is also active against multiple types of cancer cells, including carcinoma cell lines and multidrug resistant cells.

Formula: C₂₃H₂₆N₂O₄F₂

Purity: Min. 95%

Molecular weight: 432.47 g/mol

Ref: 3D-IGS-3641-PI

DAPT

CAS: 208255-80-5

Inhibitor of proteaseγ‐secretase, which allows to modulate of the activity of γ‐secretase substrates Notch, E-cadherin, ErbB4, and amyloid precursor protein (APP). The compound can inhibit the growth of tongue carcinoma cells by arresting cell cycle in G0–G1 phase, modulate the activity of Notch1 receptor and Caspase-3 protease and induce apoptosis. It was also demonstrated that this inhibitor reduces the levels of β-amyloid peptide in the brain of mice model for Alzheimer’s disease. This compound also enhances the neuronal differentiation embryonic cells.

Formula: C₂₃H₂₆O₄N₂F₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 432.46 g/mol

Ref: 3D-FT34136

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu

CAS: 208255-80-5

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a peptide that is an inhibitor of Protein interactions. It blocks the binding of the enzyme to its substrate and prevents the conversion of substrate to product. This peptide was used as a research tool for studying protein interactions in cell biology and as an activator for Ligands. This peptide can be used as a reagent for antibody production. The purity of this peptide is high and it has been shown to have no adverse effects in animal research studies.

Formula: C₂₃H₂₆N₂O₄F₂

Purity: Min. 95%

Molecular weight: 432.46 g/mol

Ref: 3D-IGS-3219-V