CAS 20830-75-5

Digoxin

Description:

Digoxin is a cardiac glycoside derived from the leaves of the foxglove plant (Digitalis purpurea) and is primarily used in the treatment of various heart conditions, particularly atrial fibrillation and heart failure. It functions by inhibiting the sodium-potassium ATPase pump, leading to an increase in intracellular calcium concentrations, which enhances cardiac contractility. Digoxin is characterized by its relatively narrow therapeutic window, meaning that the difference between an effective dose and a toxic dose is small, necessitating careful monitoring of serum levels in patients. It is typically administered orally or intravenously and is known for its potential side effects, which can include gastrointestinal disturbances, visual changes, and arrhythmias. The substance has a molecular formula of C41H64O14 and a molecular weight of approximately 780.94 g/mol. Digoxin's pharmacokinetics are influenced by factors such as renal function and interactions with other medications, making individualized dosing essential for safe and effective use.

Formula: C₄₁H₆₄O₁₄

InChI: InChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1

InChI key: InChIKey=LTMHDMANZUZIPE-PUGKRICDSA-N

SMILES: O[C@@]12[C@@](C)([C@H](CC1)C3=CC(=O)OC3)[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](O)[C@H](O)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]

Synonyms:

• (3beta,5beta,12beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3beta,5beta,8xi,9xi,12beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• 12β-Hydroxydigitoxin
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Cardigox
• Cardiogoxin
• Cardioxin
• Cardixin
• Cardoxin
• Chloroformic digitalin
• Coragoxine
• Cordioxil
• Davoxin
• Digacin
• Digicor
• Digitek
• Digitoxin, 12β-hydroxy-
• Digomal
• Digon
• Digosin
• Digoxin (FDA)
• Digoxin Nativelle
• Digoxina
• Digoxine
• Dilanacin
• Dixina
• Dokim
• Dynamos
• Eudigox
• Fargoxin
• Grexin
• Homolle's digitalin
• Lanacordin
• Lanacrist
• Lanicor
• Lanikor
• Lanocardin
• Lanorale
• Lanoxicaps
• Lanoxin
• Lanoxin PG
• Lenoxicaps
• Lenoxin
• Longdigox
• Mapluxin
• Natigoxin
• NeoDioxanin
• Novodigal-Amp.
• Nsc 95100
• Purgoxin
• Rougoxin
• Stillacor
• Toloxin
• Vanoxin
• (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide

Digoxin, 96%

CAS: 20830-75-5

Digoxin, 96%, Thermo Scientific Chemicals

Formula: C₄₁H₆₄O₁₄

Purity: 96%

Color and Shape: Powder, White

Molecular weight: 780.95

Ref: 02-B21902

Digoxin

CAS: 20830-75-5

Digoxin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₄₁H₆₄O₁₄

Purity: (HPLC) ≥95%

Color and Shape: Powder

Molecular weight: 780.95

Ref: 11-0830

Digoxin 1.0 mg/ml in Methanol

CAS: 20830-75-5

Color and Shape: Single Solution

Ref: 61-AMP0212.00-01

Digoxin, 1mg/ml in Methanol

CAS: 20830-75-5

Color and Shape: Single Solution

Ref: LP-DOX-1921-1LM

Digoxin

CAS: 20830-75-5

Color and Shape: Neat

Ref: 61-FOR0212.00

DIGOXIN FOR PEAK IDENTIFICATION CRS

CAS: 20830-75-5

DIGOXIN FOR PEAK IDENTIFICATION CRS

Formula: C₄₁H₆₄O₁₄

Molecular weight: 780.9385

Ref: 41-Y0000554

DIGOXIN CRS

CAS: 20830-75-5

DIGOXIN CRS

Formula: C₄₁H₆₄O₁₄

Color and Shape: White. Whitish. Powder.

Molecular weight: 780.9385

Ref: 41-D1900000

DIGOXIN RS

CAS: 20830-75-5

DIGOXIN RS

Formula: C₄₁H₆₄O₁₄

Molecular weight: 780.9385

Ref: 41-ICRS0289

Digoxin

CAS: 20830-75-5

Other glycosides, natural or reproduced by synthesis, a

Formula: C₄₁H₆₄O₁₄

Color and Shape: White Translucent Crystalline Powder Crystals

Molecular weight: 780.94

Ref: 45-1200000

Digoxin

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Purity: ≥ 94.5% (anhydrous basis)

Color and Shape: White to off-white powder

Molecular weight: 780.95

Ref: 7W-GC1807

Digoxin

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Color and Shape: White To Off-White Solid

Molecular weight: 780.95

Ref: 4Z-D-751

Digoxin, USP grade

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Molecular weight: 780.95

Ref: 7W-GC1100

Digoxin

CAS: 20830-75-5

Digoxin

Purity: 96%

Color and Shape: White Solid

Molecular weight: 780.94g/mol

Ref: 54-BID2190

Digoxin-d3

CAS: 127299-95-0, 20830-75-5

Formula: C₄₁H₆₁D₃O₁₄

Color and Shape: Off-White Solid

Molecular weight: 783.98

Ref: 4Z-D-752

Digoxin

Controlled Product

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Color and Shape: Neat

Molecular weight: 780.94

Ref: 04-C12633850

Digoxin

CAS: 20830-75-5

Color and Shape: White

Ref: LP-DOX-1921-10

Digoxin

CAS: 20830-75-5

Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure. Digoxin and other cardiac glycosides can inhibit hypoxia-inducible factor 1 (HIF-1)α synthesis and block tumor growth.

Formula: C₄₁H₆₄O₁₄

Purity: 95%~99%

Molecular weight: 780.949

Ref: BP-BP0490

Digoxin

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Purity: >96.0%(HPLC)

Color and Shape: White to Almost white powder to crystaline

Molecular weight: 780.95

Ref: 3B-D1828

Digoxin

Controlled Product

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Color and Shape: Neat

Molecular weight: 780.94

Ref: 86-MM0212.00

Digoxin RS

CAS: 20830-75-5

Color and Shape: Colorless To White

Ref: 2K-1065000021

Digoxin

Controlled Product

CAS: 20830-75-5

Applications Cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Aronson, J.K., et al.: Clin. Pharmacokinet, 5,137 (1980), Foss, P.R.B., Anal. Profiles Drug Subs., 9, 207 (1980),

Formula: C₄₁H₆₄O₁₄

Color and Shape: White

Molecular weight: 780.94

Ref: TR-D446575

12β-Hydroxydigitoxin

CAS: 20830-75-5

Please enquire for more information about 12beta-Hydroxydigitoxin including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₄₁H₆₄O₁₄

Molecular weight: 780.95 g/mol

Ref: 3D-J-013666

Digoxin

CAS: 20830-75-5

Digoxin and its derivatives are the most widely used as cardiac glycosides. Digoxin is isolated from the foxglove plant, Digitalis lanata, and has pharmacokinetic properties that are intermediate between digitoxin and the short acting strophanthus glycosides. Digoxin is regarded as the drug of choice for the treatment of congestive heart failure as its main assets are the rapid onset of action, good absorption ratio and the medium half-life which makes toxic reactions easier to manage (Albrecht, 1999).

Formula: C₄₁H₆₄O₁₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 780.94 g/mol

Ref: 3D-OD01513

Digoxin extrapure, 95%

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Purity: min. 95%

Color and Shape: White to off white, Crystalline powder, Clear

Molecular weight: 780.94

Ref: SR-48712