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CAS 2086298-33-9

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  • (S,R,S)-AHPC-Boc derivative 1
    Targetmol
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    (S,R,S)-AHPC-Boc derivative 1

    CAS:
    <p>(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).</p>
    Formula:C28H40N4O6S
    Color and Shape:Solid
    Molecular weight:560.705

    Ref: TM-T206790