Product Information
Name:(S,R,S)-AHPC-Boc derivative 1
Synonyms:
- VH032-Boc derivative 1
Brand:Targetmol
Description:(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).
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Chemical properties
Molecular weight:560.705
Formula:C28H40N4O6S
Color/Form:Solid
Technical inquiry about: (S,R,S)-AHPC-Boc derivative 1
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