CAS 20874-52-6

Saikosaponin D

Description:

Saikosaponin D is a triterpenoid saponin primarily derived from the roots of the plant Bupleurum falcatum, commonly known for its use in traditional medicine. It is characterized by its complex structure, which includes a steroid-like backbone with various sugar moieties attached, contributing to its biological activity. Saikosaponin D exhibits a range of pharmacological properties, including anti-inflammatory, hepatoprotective, and immunomodulatory effects. Its mechanism of action is thought to involve the modulation of various signaling pathways, including those related to apoptosis and cell proliferation. Additionally, Saikosaponin D has been studied for its potential anticancer properties, showing promise in inhibiting tumor growth in various cancer cell lines. The substance is typically soluble in water and organic solvents, making it suitable for various extraction and formulation processes. As with many natural compounds, further research is ongoing to fully elucidate its therapeutic potential and mechanisms of action, as well as to explore its safety and efficacy in clinical applications.

Formula: C₄₂H₆₈O₁₃

InChI: InChI=1S/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3/t21-,22-,23-,24-,25?,26-,27+,28+,29-,30+,31-,32-,33+,34+,35+,37+,38+,39-,40+,41-,42+/m1/s1

InChI key: InChIKey=KYWSCMDFVARMPN-VFDNYBEVSA-N

SMILES: C[C@]12[C@@]3(C4([C@@](CO3)([C@H](O)C1)CCC(C)(C)C4)[H])C=C[C@]5([C@@]2(C)CC[C@@]6([C@]5(C)CC[C@H](O[C@H]7[C@H](O)[C@@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](O)[C@@H](C)O7)[C@]6(CO)C)[H])[H]

Synonyms:

• (3beta,13alpha,16alpha,17alpha)-16,23-dihydroxy-13,28-epoxyolean-11-en-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl-beta-D-galactopyranoside
• (3beta,16alpha)-16,23-Dihydroxy-13,28-epoxyolean-11-en-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl-beta-D-galactopyranoside
• (3β,4α,16α)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-galactopyranoside
• beta-D-galactopyranoside, (3beta,16alpha)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl-
• sailkosaponin D
• β-<span class="text-smallcaps">D</smallcap>-Galactopyranoside, (3β,4α,16α)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-<smallcap>D</span>-glucopyranosyl-
• Saikosaponin D
• (3β,4α,16α)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside
• β-D-Galactopyranoside, (3β,4α,16α)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-

β-D-Galactopyranoside, (3β,4α,16α)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-

CAS: 20874-52-6

Formula: C₄₂H₆₈O₁₃

Purity: %

Color and Shape: Solid

Molecular weight: 780.9815

Ref: IN-DA002JVD

Saikosaponin D

CAS: 20874-52-6

Saikosaponin D

Formula: C₄₂H₆₈O₁₃

Purity: ≥98%

Molecular weight: 780.993

Ref: 54-BUP10684

Saikosaponin D

CAS: 20874-52-6

(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-3,5-Dihydroxy-2-(((3S,4R,4aR,6aR,6bS,8R,8aS,12aR,12bS,14aR,14bS)-8-hydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,9,10,11,12,12a,14a,14b-octadecahydro-12b,8a-(epoxymethano)picen-3-yl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Formula: C₄₂H₆₈O₁₃

Purity: 98+%

Molecular weight: 780.98

Ref: IN-DG32606

Saikosaponin D

CAS: 20874-52-6

Formula: C₄₂H₆₈O₁₃

Molecular weight: 780.98

Ref: 7W-GC1918

Saikosaponin D

CAS: 20874-52-6

SaikosaponinD (SSd) is a major triterpenoid saponin derivative from Radix bupleuri, which has been long used in Chinese traditional medicine for treatment of various inflammation-related diseases; it shows potent anti-inflammatory activity through inhibitory effects on NF-κB activation and thereby on iNOS, COX-2 and pro-inflammatory cytokines.

Formula: C₄₂H₆₈O₁₃

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 780.993

Ref: BP-BP1242

Saikosaponin D

CAS: 20874-52-6

Formula: C₄₂H₆₈O₁₃

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 780.99

Ref: 3B-A3405

Saikosaponin D

CAS: 20874-52-6

Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.

Formula: C₄₂H₆₈O₁₃

Purity: 98.34% - 99.73%

Color and Shape: White Solid

Molecular weight: 780.98

Ref: TM-T3913

Saikosaponin D

CAS: 20874-52-6

Natural glycoside

Formula: C₄₂H₆₈O₁₃

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 781

Ref: 5G-89527

Saikosaponin D

Controlled Product

CAS: 20874-52-6

Applications Saikosaponin D is an inhibitor of proliferation of human prostate cancer cells through arresting the cell cycle.
References Yao, M. et al.: Mol. Med. Rep., 10, 365 (2014); Li, Z. et al.: Prog. Neuro-Psychopharm. Biol. Psych., 53, 80 (2014);

Formula: C₄₂H₆₈O₁₃

Color and Shape: Neat

Molecular weight: 780.98

Ref: TR-S083915

Saikosaponin D

CAS: 20874-52-6

Saikosaponin D is a bioactive compound, specifically a triterpenoid saponin, which is derived from the roots of Bupleurum species, plants commonly used in traditional Chinese medicine. Its mode of action involves modulating key pathways in inflammation and apoptosis. This compound targets cellular mechanisms by interacting with inflammatory mediators and apoptotic proteins, thereby influencing immune responses and cellular survival.

Formula: C₄₂H₆₈O₁₃

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 780.98 g/mol

Ref: 3D-OS09508