CAS 2093414-37-8

Formula: C26H30ClN7O3S

InChI: InChI=1S/C26H30ClN7O3S/c1-16(2)38(35,36)23-8-6-5-7-19(23)29-25-18(27)15-28-26(31-25)30-20-13-17-9-10-24-32-33(3)11-12-34(24)21(17)14-22(20)37-4/h5-8,13-16H,9-12H2,1-4H3,(H2,28,29,30,31)

InChI key: CKZWESXBMQBAAD-UHFFFAOYSA-N

SMILES: CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C4C(=C3)CCC5=NN(CCN54)C)OC

ALK-IN-24

CAS: 2093414-37-8

ALK-IN-24 is an orally active ALK inhibitor with an IC₅₀ value of 1.7 nM. It also inhibits the insulin receptor kinase, with an IC₅₀ value of 6 nM. ALK-IN-24 suppresses the proliferation of lung adenocarcinoma cells and hinders ALK-driven tumor growth in xenograft mouse models. It is applicable for research related to non-small cell lung cancer.

Formula: C₂₆H₃₀ClN₇O₃S

Molecular weight: 556.08

Ref: TM-T218696