CAS 209410-46-8

5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

Description:

5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one, with the CAS number 209410-46-8, is a synthetic organic compound characterized by its complex heterocyclic structure. This compound features a pyrimidine and pyridazine core, which contributes to its potential biological activity. The presence of dichlorophenyl and difluorophenyl groups indicates significant halogenation, which can enhance lipophilicity and influence the compound's interaction with biological targets. The thioether linkage introduces sulfur into the structure, potentially affecting its reactivity and solubility. This compound may exhibit pharmacological properties, making it of interest in medicinal chemistry, particularly in the development of new therapeutic agents. Its specific characteristics, such as melting point, solubility, and spectral data, would typically be determined through experimental methods. Overall, the unique structural features of this compound suggest it could play a role in various chemical and biological applications.

Formula: C₁₉H₉Cl₂F₂N₃OS

InChI: InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H

InChI key: InChIKey=VEPKQEUBKLEPRA-UHFFFAOYSA-N

SMILES: O=C1C(=C2N(N=C(SC3=C(F)C=C(F)C=C3)C=C2)C=N1)C4=C(Cl)C=CC=C4Cl

Synonyms:

• 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one
• 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one
• 6H-Pyrimido[1,6-b]pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-
• Neflamapimod
• Vd 31745
• Vrt 031745
• Vx-745
• 5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

6H-Pyrimido[1,6-b]pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-

CAS: 209410-46-8

Formula: C₁₉H₉Cl₂F₂N₃OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 436.2621

Ref: IN-DA002K7Y

Neflamapimod

CAS: 209410-46-8

Neflamapimod

Purity: ≥95%

Molecular weight: 436.26g/mol

Ref: 54-BUP10374

VX-745

CAS: 209410-46-8

VX-745

Formula: C₁₉H₉Cl₂F₂N₃OS

Purity: 99.8% (Typical Value in Batch COA)

Color and Shape: yellow solid

Molecular weight: 436.26g/mol

Ref: 54-BISN0180

VX-745

CAS: 209410-46-8

Ref: 7W-GW2962

Neflamapimod

CAS: 209410-46-8

Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.

Formula: C₁₉H₉Cl₂F₂N₃OS

Purity: 97.88% - 99.75%

Color and Shape: Solid

Molecular weight: 436.26

Ref: TM-T6089

5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one

CAS: 209410-46-8

Formula: C₁₉H₉Cl₂F₂N₃OS

Purity: 95.0%

Molecular weight: 436.26

Ref: 10-F092709

VX 745

Controlled Product

CAS: 209410-46-8

Applications VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.
References Haddad, J.J.: Curr. Opin. Invest. Drugs, 2, 1070 (2001); Duffy, J.P. et al.: ACS Med. Chem. Lett., 2, 758 (2011); Bagley, M.C. et al.: Pharmaceuticals, 3, 1842 (2010);

Formula: C₁₉H₉Cl₂F₂N₃OS

Color and Shape: Neat

Molecular weight: 436.26

Ref: TR-V900500

Neflamapimod

CAS: 209410-46-8

5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one (NVP-BEZ235) is a molecule that inhibits the activity of the phosphoinositide 3 kinase (PI3K) pathway. This pathway regulates cell growth and survival by controlling cellular energy production and distribution. The PI3K pathway is active in a number of cancers, including colorectal cancer and acute myeloid leukemia. NVP-BEZ235 has been shown to be effective for treating bowel disease and inflammatory bowel disease in clinical trials. In addition, it is also an effective treatment for cancer with platinum based chemotherapy. The most common side effects are nausea, vomiting, diarrhea, constipation, anorexia, fatigue and headache.

Formula: C₁₉H₉Cl₂F₂N₃OS

Purity: Min. 95%

Molecular weight: 436.26 g/mol

Ref: 3D-FD139233