CAS 209783-80-2
:Entinostat
Description:
Entinostat, with the CAS number 209783-80-2, is a small molecule that functions primarily as a histone deacetylase (HDAC) inhibitor. It is characterized by its ability to modulate gene expression by altering the acetylation status of histones, which can lead to the reactivation of silenced genes, particularly those involved in tumor suppression. Entinostat is often studied in the context of cancer therapy, as it has shown potential in enhancing the efficacy of other anticancer agents and in treating various malignancies, including breast cancer and melanoma. The compound is typically administered orally and has a relatively favorable pharmacokinetic profile, allowing for systemic distribution. Its mechanism of action involves not only the inhibition of HDACs but also the modulation of various signaling pathways, contributing to its antitumor effects. Additionally, entinostat has been investigated for its immunomodulatory properties, making it a candidate for combination therapies in oncology. As with many therapeutic agents, its use may be accompanied by side effects, necessitating careful monitoring during treatment.
Formula:C21H20N4O3
InChI:InChI=1/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
InChI key:InChIKey=INVTYAOGFAGBOE-UHFFFAOYSA-N
SMILES:C(NC1=C(N)C=CC=C1)(=O)C2=CC=C(CNC(OCC=3C=CC=NC3)=O)C=C2
Synonyms:- (Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate
- Carbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester
- Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester
- Ms 27-275
- Ms 275
- Ms 275-27
- N-[4-[N-(2-Aminophenyl)carbamoyl]benzyl]carbamic acid 3-pyridylmethyl ester
- N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester
- Pyridin-3-Ylmethyl {4-[(2-Aminophenyl)Carbamoyl]Benzyl}Carbamate
- Sndx 275
- MS-275 (Entinostat)
- Nsc706995
- Entinostat(NSC-706995)
- [4-(2-Amino-phenylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester
- Entinostat/MS-275
- Entinostat
- entinostat(HDAC inhibitor)
- Entinostat (MS-275,SNDX-275)
- entinostat
- MS-275,Entinostat,SNDX-275
- 3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide
- See more synonyms
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Found 9 products.
Entinostat
CAS:Formula:C21H20N4O3Purity:>97.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:376.42(Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate
CAS:Formula:C21H20N4O3Purity:98%Color and Shape:SolidMolecular weight:376.4085Entinostat
CAS:Formula:C21H20N4O3Purity:≥ 98.0%Color and Shape:Off-white to tan solid or powderMolecular weight:376.41Pyridin-3-Ylmethyl 4-((2-Aminophenyl)Carbamoyl)Benzylcarbamate
CAS:Pyridin-3-Ylmethyl 4-((2-Aminophenyl)Carbamoyl)BenzylcarbamatePurity:98%Molecular weight:376.41g/molEntinostat
CAS:<p>Entinostat (MS-275) is an HDAC class I with oral activity. Entinostat has antitumor activity. Cost-effective and quality-assured.</p>Formula:C21H20N4O3Purity:98% - 99.74%Color and Shape:SolidMolecular weight:376.41Entinostat
CAS:<p>Inhibits histone deacetylase (HDAC)</p>Formula:C21H20N4O3Purity:Min. 95%Color and Shape:Off-White PowderMolecular weight:376.15354Entinostat(MS-27-275)
CAS:Controlled Product<p>Applications Entinostat is an emerging HDACi (histone deacetylase inhibitor). Entinostat is used for treatment of solid tumors and hematologic malignancies. Potent Histone deacetylase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hu, E., et al.: J. Pharmacol. Exp. Ther., 307, 720 (2003), Maggio, S., et al.: Cancer Res., 64, 2590 (2004), Gojo, I., et al.: Blood, 109, 2781 (2007), Xu, W; Oncogene, 26, 5541 (2007),<br></p>Formula:C21H20N4O3Color and Shape:NeatMolecular weight:376.41
