CAS 209783-80-2: Entinostat

Description: Entinostat, with the CAS number 209783-80-2, is a small molecule that functions primarily as a histone deacetylase (HDAC) inhibitor. It is characterized by its ability to modulate gene expression by altering the acetylation status of histones, which can lead to the reactivation of silenced genes, particularly those involved in tumor suppression. Entinostat is often studied in the context of cancer therapy, as it has shown potential in enhancing the efficacy of other anticancer agents and in treating various malignancies, including breast cancer and melanoma. The compound is typically administered orally and has a relatively favorable pharmacokinetic profile, allowing for systemic distribution. Its mechanism of action involves not only the inhibition of HDACs but also the modulation of various signaling pathways, contributing to its antitumor effects. Additionally, entinostat has been investigated for its immunomodulatory properties, making it a candidate for combination therapies in oncology. As with many therapeutic agents, its use may be accompanied by side effects, necessitating careful monitoring during treatment.

Formula: C₂₁H₂₀N₄O₃

InChI: InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)

InChI key: InChIKey=INVTYAOGFAGBOE-UHFFFAOYSA-N

SMILES: O=C(OCC=1C=NC=CC1)NCC2=CC=C(C=C2)C(=O)NC=3C=CC=CC3N

Synonyms:

• (Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate
• Carbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester
• Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester
• Ms 27-275
• Ms 275
• Ms 275-27
• N-[4-[N-(2-Aminophenyl)carbamoyl]benzyl]carbamic acid 3-pyridylmethyl ester
• N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester
• Pyridin-3-Ylmethyl {4-[(2-Aminophenyl)Carbamoyl]Benzyl}Carbamate
• Sndx 275
• MS-275 (Entinostat)

Entinostat

CAS: 209783-80-2

• Formula: C₂₁H₂₀N₄O₃
• Purity: >97.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 376.42

Carbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester

CAS: 209783-80-2

• Formula: C₂₁H₂₀N₄O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 376.4085

Entinostat

CAS: 209783-80-2

• Formula: C₂₁H₂₀N₄O₃
• Purity: ≥ 98.0%
• Color and Shape: Off-white to tan solid or powder
• Molecular weight: 376.41

Entinostat

CAS: 209783-80-2

• Purity: 99.51%
• Molecular weight: 376.41g/mol

Pyridin-3-Ylmethyl 4-((2-Aminophenyl)Carbamoyl)Benzylcarbamate

CAS: 209783-80-2

• Purity: 98%+
• Molecular weight: 376.41g/mol

Entinostat

CAS: 209783-80-2

Entinostat (MS-275) is an HDAC class I with oral activity. Entinostat has antitumor activity. Cost-effective …

• Formula: C₂₁H₂₀N₄O₃
• Purity: 98% - 99.52%
• Color and Shape: Solid
• Molecular weight: 376.41

Entinostat, Free Base

CAS: 209783-80-2

• Purity: 99.0%
• Color and Shape: Solid
• Molecular weight: 376.4159851074219

Entinostat

CAS: 209783-80-2

Inhibits histone deacetylase (HDAC)

• Formula: C₂₁H₂₀N₄O₃
• Purity: Min. 95%
• Color and Shape: Off-White Powder
• Molecular weight: 376.15354

Entinostat(MS-27-275)

CAS: 209783-80-2

Applications Entinostat is an emerging HDACi (histone deacetylase inhibitor). Entinostat is used for treatment of …

• Formula: C₂₁H₂₀N₄O₃
• Color and Shape: Neat
• Molecular weight: 376.41