CAS 210179-46-7

JWH 081

Description:

JWH-081 is a synthetic cannabinoid that belongs to a class of compounds known as indole derivatives. It was developed by John W. Huffman and is primarily known for its psychoactive effects, which mimic those of natural cannabinoids found in cannabis. JWH-081 acts as a potent agonist at the cannabinoid receptors, particularly CB1 and CB2, leading to effects such as altered mood, perception, and cognition. The substance is typically encountered in various forms, including powders and as an ingredient in synthetic cannabis products. Its chemical structure features a naphthalene ring and an alkyl side chain, contributing to its binding affinity and activity at cannabinoid receptors. Due to its psychoactive properties, JWH-081 has been subject to legal restrictions in many jurisdictions, and its use can pose health risks, including potential addiction and adverse psychological effects. As a synthetic compound, it is often associated with the broader category of "designer drugs," which are frequently modified to evade legal regulations.

Formula: C₂₅H₂₅NO₂

InChI: InChI=1S/C25H25NO2/c1-3-4-9-16-26-17-22(19-11-7-8-13-23(19)26)25(27)21-14-15-24(28-2)20-12-6-5-10-18(20)21/h5-8,10-15,17H,3-4,9,16H2,1-2H3

InChI key: InChIKey=UBMPKJKGUQDHRM-UHFFFAOYSA-N

SMILES: C(=O)(C=1C=2C(N(CCCCC)C1)=CC=CC2)C=3C4=C(C(OC)=CC3)C=CC=C4

Synonyms:

• (4-Methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone
• (4-Methoxy-1-naphthyl)(1-pentyl-1H-indol-3-yl)methanone
• 1-Pentyl-3-(4-Methoxynaphthoyl)Indole
• Jwh 081
• methanone, (4-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-

JWH-081, 1mg/ml in Methanol

Controlled Product

CAS: 210179-46-7

Color and Shape: Single Solution

Ref: LP-JWH-1505-1LM

JWH-081, 0.1mg/ml in Methanol

Controlled Product

CAS: 210179-46-7

Color and Shape: Single Solution

Ref: LP-JWH-1505-0.1LM

JWH-081

Controlled Product

CAS: 210179-46-7

Color and Shape: Neat

Ref: 61-FOR1275.31

JWH-081 ((4-Methoxynaphthalen-1-yl)(1-pentylindol-3-yl)methanone) 1.0 mg/ml in Acetonitrile

Controlled Product

CAS: 210179-46-7

Color and Shape: Single Solution

Ref: 61-AMP1275.31-11

JWH-081

CAS: 210179-46-7

Color and Shape: Neat

Ref: LP-JWH-1505

1-Pentyl-3-(4-methoxynaphthoyl)indole

Controlled Product

CAS: 210179-46-7

Applications 1-Pentyl-3-(4-methoxynaphthoyl)indole is an analgesic chemical which acts as cannabinoid agonist at the CB1 and CB2 receptors. Synthetic Cannabinoids
References Huffman, J., et al.: Bioorg. Med. Chem., 11, 539 (2003); De Freitas, G., et al.: Eur. J. Med. Chem., 44, 2482 (2009);

Formula: C₂₅H₂₅NO₂

Color and Shape: Neat

Molecular weight: 371.47

Ref: TR-P283600

JWH 081

Controlled Product

CAS: 210179-46-7

JWH 081 is a synthetic cannabinoid with potent anti-inflammatory properties. It has shown to be useful in the treatment of rheumatoid arthritis, multiple sclerosis, and other inflammatory diseases. JWH 081 binds to the cb2 receptor, which is found in high numbers in the immune system and has been shown to have an inhibitory effect on pro-inflammatory cytokines such as TNF-α. This drug also inhibits the production of prostaglandins by inhibiting cyclooxygenase enzymes. JWH 081 is metabolized by esterases into its active form, 11-hydroxy-JWH-081. The compound is typically administered orally or intravenously. JWH 081 is usually detectable in urine samples for up to 3 days following administration. Analytical methods include LC-MS/MS and HPLC with UV detection at 254 nm or 280 nm.

Formula: C₂₅H₂₅NO₂

Purity: Min. 95%

Molecular weight: 371.47 g/mol

Ref: 3D-FP26829