CAS 2102933-95-7

Formula: C14H22Cl2N2

InChI: InChI=1S/C14H20N2.2ClH/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12;;/h1-5,12-16H,6-10H2;2*1H/t13-,14+;;/m0../s1

InChI key: PJFZOGMSPBHPNS-WICJZZOFSA-N

SMILES: C1CNCCC1N[C@@H]2C[C@H]2C3=CC=CC=C3.Cl.Cl

GSK-LSD1 dihydrochloride

CAS: 2102933-95-7

GSK-LSD1 dihydrochloride

Formula: C₁₄H₂₂Cl₂N₂

Purity: 98.5%

Molecular weight: 289.24

Ref: 54-BUP12461

GSK-LSD1 (hydrochloride)

CAS: 2102933-95-7

Formula: C₁₄H₂₂Cl₂N₂

Purity: 98%

Molecular weight: 289.2439

Ref: IN-DA01EO5W

GSK-LSD1 dihydrochloride

CAS: 2102933-95-7

GSK-LSD1 dihydrochloride: potent LSD1 inhibitor, >1000x selective over MAO-A/B, LSD2, IC50: 16 nM.

Formula: C₁₄H₂₂Cl₂N₂

Purity: 98.72% - >99.99%

Color and Shape: Yellow Solid

Molecular weight: 289.24

Ref: TM-T2315

GSK LSD1 Dihydrochloride

Controlled Product

CAS: 2102933-95-7

Applications GSK LSD1 Dihydrochloride is an irreversible mechanism-based inhibitor of LSD1. Lysine-specific demthylase 1 (LSD1) belonges to the flavin adenine dinucleotide (FAD) family-dependant amine oxidases that include MAOs and PAOs. Inhibits cell proliferation in cancer cell lines.
References Shi, Y. et al.: Cell 119, 941 (2004); Forneris, F. J. Biol. Chem. 280, 41360 (2005);

Formula: C₁₄H₂₂Cl₂N₂

Color and Shape: Neat

Molecular weight: 342.407

Ref: TR-G797570

GSK-LSD1 dihydrochloride

CAS: 2102933-95-7

GSK-LSD1 is a potential drug for the treatment of cervical cancer and myeloid leukemia. GSK-LSD1 has been shown to induce autophagy, which is a process by which cells break down and recycle their own cellular components. This process also plays a key role in the development of bowel disease, as well as inflammatory bowel disease and leukemias. GSK-LSD1 was shown to inhibit the growth of human myeloid leukemia cells (THP-1) in vitro and reduced the number of leukemic mice with leukemia. The mechanism by which GSK-LSD1 inhibits tumor cell proliferation is unclear, but may be related to its ability to inhibit cell factor or stem cell factor expression.

Formula: C₁₄H₂₂Cl₂N₂

Purity: Min. 95%

Molecular weight: 289.24 g/mol

Ref: 3D-CJD93395