CAS 210345-03-2

L-a-Asparagine, N-acetyl-L-leucyl-L-a-glutamyl-L-histidyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-(9CI)

Description:

L-a-Asparagine, N-acetyl-L-leucyl-L-a-glutamyl-L-histidyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl] is a complex organic compound characterized by its multi-functional structure, which includes amino acid residues and a benzopyran moiety. This compound features a combination of amino acids, specifically asparagine, leucine, glutamic acid, and histidine, which contribute to its potential biological activity and interactions. The presence of the N-acetyl group suggests modifications that may enhance solubility or stability. Additionally, the trifluoromethyl group and the benzopyran structure may impart unique electronic properties, influencing the compound's reactivity and potential applications in medicinal chemistry. The CAS number 210345-03-2 identifies this specific compound in chemical databases, facilitating research and information retrieval. Overall, the characteristics of this substance suggest it may have relevance in pharmacology or biochemistry, although specific biological activities would require further investigation.

Formula: C₃₃H₃₈F₃N₇O₁₁

Synonyms:

• N-Acetyl-Leu-Glu-His-Asp 7-Amido-4-Trifluoromethylcoumarin
• N-Acetyl-Leu-Glu-His-Asp-(7-Amino-4-Trifluoromethylcoumarin)
• N-Acetyl-Leu-Glu-His-Asp-7-Amino-4-Trifluoromethylcoumarin Afc
• Ac-Leu-Glu-His-Asp-7-Amino-4-Trifluoro-Methylcoumarin
• Ac-Leu-Glu-His-Asp-Afc
• Ac-Lehd-Afc
• Caspase-9 Substrate I, Fluorogenic
• Caspase 9 Substrate 1F, Fluorogenic

Ac-Leu-Glu-His-Asp-AFC

CAS: 210345-03-2

Bachem ID: 4028699.

Formula: C₃₃H₃₈F₃N₇O₁₁

Purity: 97.2%

Molecular weight: 765.7

Ref: 01-4028699

L-α-Asparagine, N-acetyl-L-leucyl-L-α-glutamyl-L-histidyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]- (9CI)

CAS: 210345-03-2

Formula: C₃₃H₃₈F₃N₇O₁₁

Purity: 98%

Molecular weight: 765.6903

Ref: IN-DA002KQ3

Ac-LEHD-AFC Trifluoroacetic Acid Salt

Controlled Product

CAS: 210345-03-2

Applications Ac-LEHD-AFC Trifluoroacetic Acid Salt is a fluorogenic substrate that is cleaved by caspases (4,5 and 9). This activity is quantified by fluorescent detection of free AFC. Caspase-9 activation is critical for intrinsic cell death.
References Yin, Q. et al.: Mol. Cell., 22, 259 (2006); Kyewhan, P. et al.: Biochem. Biophys. Res. Comm., 347, 941 (2006);

Formula: C₃₃H₃₈F₃N₇O₁₁·x(C₂HF₃O₂)

Color and Shape: Neat

Molecular weight: 765.69 + x(114.02)

Ref: TR-A190170