CAS 210353-53-0
:Gemifloxacin mesylate
Description:
Gemifloxacin mesylate is a synthetic fluoroquinolone antibiotic that exhibits broad-spectrum antibacterial activity. It is primarily used to treat respiratory tract infections, including pneumonia and bronchitis, by inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication and transcription. The substance is characterized by its solubility in water and organic solvents, which facilitates its absorption and bioavailability. Gemifloxacin mesylate has a favorable pharmacokinetic profile, allowing for once-daily dosing. Its chemical structure includes a bicyclic core with a fluorine atom, contributing to its potency against a variety of Gram-positive and Gram-negative bacteria. The mesylate salt form enhances its stability and solubility. Common side effects may include gastrointestinal disturbances and potential effects on the central nervous system. As with other fluoroquinolones, caution is advised regarding its use in certain populations, such as those with a history of tendon disorders or myasthenia gravis. Overall, gemifloxacin mesylate is an important therapeutic agent in the management of bacterial infections.
Formula:C18H20FN5O4·CH4O3S
InChI:InChI=1/C18H20FN5O4.CH4O3S/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17;1-5(2,3)4/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27);1H3,(H,2,3,4)/b22-14+;
InChI key:InChIKey=JIYMVSQRGZEYAX-CWUUNJJBNA-N
SMILES:O=C1C=2C(N(C=C1C(O)=O)C3CC3)=NC(=C(F)C2)N4C/C(=N\OC)/C(CN)C4.S(C)(=O)(=O)O
Synonyms:- 1,8-Naphthyridine-3-carboxylic acid, 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, monomethanesulfonate
- 7-(3-Aminomethyl)-4-methoxyimino-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid mesylate
- Factive
- Floxguard
- Gemifloxacin mesylate
- Gemixa
- LB 20304a
- Sb 265805S
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Found 10 products.
Gemifloxacin Mesylate
CAS:Anti-infective agents, nesoiFormula:C18H20FN5O4·CH4O3SColor and Shape:White Light Brown SolidMolecular weight:485.491,8-Naphthyridine-3-carboxylic acid, 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, monomethanesulfonate
CAS:Formula:C19H24FN5O7SPurity:98%Color and Shape:SolidMolecular weight:485.4866Gemifloxacin mesylate
CAS:Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventuallyFormula:C19H24FN5O7SPurity:97.24% - ≥95%Color and Shape:Beige SolidMolecular weight:485.49Gemifloxacin mesilate
CAS:Formula:C19H24FN5O7SPurity:≥ 97%Color and Shape:White to off-white or beige powderMolecular weight:485.49Gemifloxacin Mesylate
CAS:Formula:C18H20FN5O4·CH4O3SColor and Shape:Off-White To Pale Yellow SolidMolecular weight:389.39 96.10Gemifloxacin Mesylate
CAS:Formula:C18H20FN5O4·CH4O3SPurity:>95.0%(HPLC)(qNMR)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:485.49(Z)-Gemifloxacin Mesilate
CAS:Applications Third generation fluorinated quinolone antibacterial.
References Wise, R., et al.: J. Antimicrob. Chemother., 44, 679 (1999), Allen, A., et al.: Antimicrob. Agents Chemother., 44, 1604 (2000), Blondeau, B., et al.: Expert Opin. Pharmacother., 5, 1117 (2004)Formula:C18H20FN5O4·CH4O3SColor and Shape:Light Beige To Light BrownMolecular weight:485.49Gemifloxacin mesylate
CAS:Gemifloxacin mesylate is a high quality, water soluble, and stable reagent that can be used as an intermediate in the preparation of complex compounds. It is also a useful building block in the synthesis of fine chemicals and research chemicals. This compound has been used as a scaffold in the synthesis of speciality chemicals with versatile building blocks for diverse chemical applications.Formula:C19H24FN5O7SPurity:Min. 95%Molecular weight:485.5 g/mol
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