CAS 210353-53-0

Gemifloxacin mesylate

Description:

Gemifloxacin mesylate is a synthetic fluoroquinolone antibiotic that exhibits broad-spectrum antibacterial activity. It is primarily used to treat respiratory tract infections, including pneumonia and bronchitis, by inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication and transcription. The substance is characterized by its solubility in water and organic solvents, which facilitates its absorption and bioavailability. Gemifloxacin mesylate has a favorable pharmacokinetic profile, allowing for once-daily dosing. Its chemical structure includes a bicyclic core with a fluorine atom, contributing to its potency against a variety of Gram-positive and Gram-negative bacteria. The mesylate salt form enhances its stability and solubility. Common side effects may include gastrointestinal disturbances and potential effects on the central nervous system. As with other fluoroquinolones, caution is advised regarding its use in certain populations, such as those with a history of tendon disorders or myasthenia gravis. Overall, gemifloxacin mesylate is an important therapeutic agent in the management of bacterial infections.

Formula: C₁₈H₂₀FN₅O₄·CH₄O₃S

InChI: InChI=1/C18H20FN5O4.CH4O3S/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17;1-5(2,3)4/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27);1H3,(H,2,3,4)/b22-14+;

InChI key: InChIKey=JIYMVSQRGZEYAX-CWUUNJJBNA-N

SMILES: O=C1C=2C(N(C=C1C(O)=O)C3CC3)=NC(=C(F)C2)N4C/C(=N\OC)/C(CN)C4.S(C)(=O)(=O)O

Synonyms:

• 1,8-Naphthyridine-3-carboxylic acid, 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, monomethanesulfonate
• 7-(3-Aminomethyl)-4-methoxyimino-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid mesylate
• Factive
• Floxguard
• Gemifloxacin mesylate
• Gemixa
• LB 20304a
• Sb 265805S

Gemifloxacin Mesylate

CAS: 210353-53-0

Anti-infective agents, nesoi

Formula: C₁₈H₂₀FN₅O₄·CH₄O₃S

Color and Shape: White Light Brown Solid

Molecular weight: 389.14993

Ref: 45-1288667

1,8-Naphthyridine-3-carboxylic acid, 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, monomethanesulfonate

CAS: 210353-53-0

Formula: C₁₉H₂₄FN₅O₇S

Purity: 99%

Color and Shape: Solid

Molecular weight: 485.4866

Ref: IN-DA002KPO

Gemifloxacin Mesylate

CAS: 210353-53-0

(Z)-7-(3-(Aminomethyl)-4-(methoxyimino)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonic acid salt

Formula: C₁₉H₂₄FN₅O₇S

Purity: 99%

Molecular weight: 485.49

Ref: IN-DG131932

Gemifloxacin Mesylate

CAS: 210353-53-0

Gemifloxacin Mesylate

Formula: C₁₈H₂₀FN₅O₄·CH₃SO₃H

Purity: 99%

Color and Shape: Solid-Powder

Molecular weight: 485.48656

Ref: 54-BISN0005

Gemifloxacin mesylate

CAS: 210353-53-0

Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually

Formula: C₁₉H₂₄FN₅O₇S

Purity: 97.24% - ≥95%

Color and Shape: Beige Solid

Molecular weight: 485.49

Ref: TM-T1492

Gemifloxacin mesilate

CAS: 210353-53-0

Formula: C₁₉H₂₄FN₅O₇S

Purity: ≥ 97%

Color and Shape: White to off-white or beige powder

Molecular weight: 485.49

Ref: 7W-GA8275

Gemifloxacin Mesylate

CAS: 210353-53-0

Formula: C₁₈H₂₀FN₅O₄·CH₄O₃S

Color and Shape: Off-White To Pale Yellow Solid

Molecular weight: 389.39 96.10

Ref: 4Z-G-042004

Gemifloxacin Mesylate

CAS: 210353-53-0

Formula: C₁₈H₂₀FN₅O₄·CH₄O₃S

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 485.49

Ref: 3B-G0617

Gemifloxacin mesylate

CAS: 210353-53-0

Formula: C₁₈H₂₀FN₅O₄·CH₄O₃S

Color and Shape: Neat

Molecular weight: 485.49

Ref: 04-C13999250

(Z)-Gemifloxacin Mesilate

CAS: 210353-53-0

Applications Third generation fluorinated quinolone antibacterial.
References Wise, R., et al.: J. Antimicrob. Chemother., 44, 679 (1999), Allen, A., et al.: Antimicrob. Agents Chemother., 44, 1604 (2000), Blondeau, B., et al.: Expert Opin. Pharmacother., 5, 1117 (2004)

Formula: C₁₈H₂₀FN₅O₄·CH₄O₃S

Color and Shape: Neat

Molecular weight: 485.49

Ref: TR-G336000

Gemifloxacin mesylate

CAS: 210353-53-0

Gemifloxacin mesylate is a high quality, water soluble, and stable reagent that can be used as an intermediate in the preparation of complex compounds. It is also a useful building block in the synthesis of fine chemicals and research chemicals. This compound has been used as a scaffold in the synthesis of speciality chemicals with versatile building blocks for diverse chemical applications.

Formula: C₁₉H₂₄FN₅O₇S

Purity: Min. 95%

Molecular weight: 485.5 g/mol

Ref: 3D-FG182380

Gemifloxacin Mesylate

CAS: 210353-53-0

Formula: C₁₈H₂₀FN₅O₄CH₄O₃S

Molecular weight: 389.39 : 96.1

Ref: ST-EA-CP-G30005