CAS 210829-30-4

Gemcitabine elaidate

Description:

Gemcitabine elaidate is a chemical compound that serves as a prodrug of gemcitabine, an antineoplastic agent used primarily in cancer therapy. It is characterized by its ability to enhance the solubility and bioavailability of gemcitabine, which is crucial for effective drug delivery. The compound is typically presented as a white to off-white solid and is soluble in organic solvents, which facilitates its formulation in various pharmaceutical preparations. Gemcitabine elaidate undergoes enzymatic conversion in the body to release gemcitabine, allowing it to exert its cytotoxic effects on rapidly dividing cancer cells. The compound's mechanism of action involves the inhibition of DNA synthesis, making it effective against a range of malignancies, including pancreatic and non-small cell lung cancer. Additionally, its pharmacokinetic properties are designed to optimize therapeutic outcomes while minimizing side effects associated with conventional gemcitabine administration. Overall, gemcitabine elaidate represents a strategic advancement in cancer treatment, aiming to improve patient responses and treatment efficacy.

Formula: C₂₇H₄₃F₂N₃O₅

Synonyms:

• Gemcitabine elaidate(CP-4126
• GeMcitabine 5'-elaidate
• CP 4126
• CS-1569
• GeMcitabine elaidate
• Cytidine, 2'-deoxy-2',2'-difluoro-, 5'-(9E)-9-octadecenoate
• CP-4126 (LVT derivative of Gemcitabine)
• CO-101:CP-4126:Gemcitabineelaidate
• CO-101; CP-4126; GEMCITABINE 5'-ELAIDATE
• CO-101; CO101; CO 101; CP-4126; CP4126; CP 4126; GEMCITABINE ELAIDATE

(E)-((2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl octadec-9-enoate

CAS: 210829-30-4

(E)-((2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl octadec-9-enoate

Purity: 96%

Molecular weight: 527.65g/mol

Ref: 54-PC1007933

CP-4126 (LVT derivative of Gemcitabine)

CAS: 210829-30-4

Ref: 7W-GN3052

Gemcitabine elaidate

CAS: 210829-30-4

Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with

Formula: C₂₇H₄₃F₂N₃O₅

Color and Shape: Solid

Molecular weight: 527.64

Ref: TM-T15378

Gemcitabine 5'-elaidate

CAS: 210829-30-4

Gemcitabine 5'-elaidate is an analog of gemcitabine that has hydrophobic properties. It has been shown to be active against solid tumours, including lung cancer. In a study on murine xenografts, gemcitabine 5'-elaidate was found to have the same degree of efficacy as gemcitabine in reducing tumour growth and increasing survival time. Gemcitabine 5'-elaidate also has good antitumour activity against infectious diseases such as HIV and malaria, which may be due to its ability to bind to the epidermal growth factor receptor (EGFR) on the surface of cells. This binding prevents EGFR from initiating cellular signaling.

Formula: C₂₇H₄₃F₂N₃O₅

Purity: Min. 95%

Molecular weight: 527.66 g/mol

Ref: 3D-NC05399