
CAS 2139253-69-1
:Naloxone EP Impurity F
Description:
Naloxone EP Impurity F, with the CAS number 2139253-69-1, is a chemical compound related to naloxone, an opioid antagonist used primarily in the treatment of opioid overdose. As an impurity, it is typically a byproduct of the synthesis or degradation of naloxone and may not possess the therapeutic properties of the parent compound. The characteristics of this impurity can include its molecular structure, which may differ slightly from naloxone, affecting its solubility, stability, and reactivity. Impurities like Naloxone EP Impurity F are often characterized by their physical properties, such as melting point, boiling point, and spectral data (e.g., NMR, IR, MS) that help in identifying and quantifying them in pharmaceutical formulations. Regulatory guidelines often require the assessment of such impurities to ensure the safety and efficacy of drug products. Understanding the characteristics of impurities is crucial for quality control in pharmaceutical manufacturing and compliance with pharmacopoeial standards.
Formula:C19H21NO5
InChI:InChI=1S/C19H21NO5/c1-2-8-20-9-7-18-13-10-3-4-11(21)15(13)25-17(18)12(22)5-6-19(18,24)16(20)14(10)23/h2-4,14,16-17,21,23-24H,1,5-9H2/t14-,16-,17+,18+,19-/m1/s1
InChI key:INQPEYLRYLSPCY-GYFISPQKSA-N
SMILES:C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1[C@@H](C5=C3C(=C(C=C5)O)O4)O)O
Synonyms:- Naloxone-013
- Naloxone EP Impurity F
- Morphinan-6-one, 4,5-epoxy-3,10,14-trihydroxy-17-(2-propen-1-yl)-, (5α,10β)-
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10beta-Hydroxy Naloxone (1mg/ml in Acetonitrile)
CAS:Controlled ProductFormula:C19H21NO5Color and Shape:Single SolutionMolecular weight:343.3710Beta-Hydroxy Naloxone
CAS:Controlled ProductImpurity Naloxone EP Impurity F
Applications 10β-Hydroxy Naloxone is hydroxylated analog of the opioid antagonist Naloxone (N285000).
References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967), McNicholas, L.F., et al.: Drugs, 27, 81 (1984), Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985), Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)Formula:C19H21NO5Color and Shape:NeatMolecular weight:343.37

