CAS 2140-67-2

N2,N2-Dimethylguanosine

Description:

N2,N2-Dimethylguanosine is a modified nucleoside that is derived from guanosine, featuring two methyl groups attached to the nitrogen atoms at the N2 position of the purine base. This modification can influence the stability and functionality of RNA molecules, particularly in the context of tRNA and rRNA, where it plays a role in the proper folding and function of these essential biomolecules. The presence of methyl groups can enhance the resistance of RNA to degradation and may also affect the interaction of RNA with proteins and other nucleic acids. N2,N2-Dimethylguanosine is often studied in the context of epitranscriptomics, which examines the chemical modifications of RNA and their implications for gene expression and regulation. Its unique structural characteristics contribute to its biological significance, making it a subject of interest in molecular biology and biochemistry research. Additionally, the compound is identified by its CAS number 2140-67-2, which is used for regulatory and identification purposes in chemical databases.

Formula: C₁₂H₁₇N₅O₅

InChI: InChI=1S/C12H17N5O5/c1-16(2)12-14-9-6(10(21)15-12)13-4-17(9)11-8(20)7(19)5(3-18)22-11/h4-5,7-8,11,18-20H,3H2,1-2H3,(H,14,15,21)/t5-,7-,8-,11-/m1/s1

InChI key: InChIKey=RSPURTUNRHNVGF-IOSLPCCCSA-N

SMILES: O=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)NC(N(C)C)=N1

Synonyms:

• 2,2-Dimethylguanosine
• 2-Dimethylamino-6-oxypurine riboside
• Guanosine, N,N-dimethyl-
• N(2),N(2)-Dimethylguanosine
• N,N-dimethylguanosine
• N²,N²-Dimethylguanosine
• N2,N2-Dimethylguanosine

N,N-Dimethylguanosine

CAS: 2140-67-2

Formula: C₁₂H₁₇N₅O₅

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 311.30

Ref: 3B-D6076

N,N-Dimethylguanosine

CAS: 2140-67-2

Formula: C₁₂H₁₇N₅O₅

Purity: 99%

Color and Shape: Solid

Molecular weight: 311.2939

Ref: IN-DA0072K8

2-Dimethylaminoguanosine

CAS: 2140-67-2

Ref: 7W-GN2013

N,N-Dimethylguanosine

CAS: 2140-67-2

N,N-Dimethylguanosine

Purity: 95%

Molecular weight: 311.29g/mol

Ref: 54-OR1023955

N2,N2-Dimethylguanosine

CAS: 2140-67-2

N2,N2-Dimethylguanosine

Purity: ≥98%

Molecular weight: 311.29g/mol

Ref: 54-BUP10056

N2,N2-Dimethylguanosine

CAS: 2140-67-2

Urinary N2,N2-Dimethylguanosine levels higher in colorectal cancer than in villous adenoma or healthy adults.

Formula: C₁₂H₁₇N₅O₅

Purity: 98.01%

Color and Shape: White Solid

Molecular weight: 311.29

Ref: TM-TQ0193

2-(Dimethylamino)guanosine

Controlled Product

CAS: 2140-67-2

Applications 2-(Dimethylamino)guanosine (cas# 2140-67-2) is a compound useful in organic synthesis.

Formula: C₁₂H₁₇N₅O₅

Color and Shape: Neat

Molecular weight: 311.29

Ref: TR-D460850

2-(Dimethylamino)guanosine-d6

Controlled Product

CAS: 2140-67-2

Applications 2-(Dimethylamino)guanosine-d6 is deuterium labeled 2-(Dimethylamino)guanosine (D460850), which can be used to investigate the mechanism of 2'-deoxyoxanosine formation from 2'-deoxyguanosine and nitrous acid. In addition, 2-(Dimethylamino)guanosine can also be employed in mass spectrometry to quantify tRNA modifications related to cellular stress response in Saccharomyces cerevisiae.
References Suzuki, T., et al.: Nucleic Acids Res 28, 544 (2000); Chan, C. T. et al.: PLoS Genet 6, e1001247 (2010).

Formula: C₁₂H₁₁D₆N₅O₅

Color and Shape: White To Off-White

Molecular weight: 317.33

Ref: TR-D460852

N2,N2-Dimethylguanosine

CAS: 2140-67-2

N2,N2-Dimethylguanosine is a purine nucleoside that is found in human serum. It belongs to the group of purines and has been shown to be involved in energy metabolism. N2,N2-Dimethylguanosine has been shown to be present at high levels in patients with autoimmune diseases such as rheumatoid arthritis. The x-ray crystal structures of wild-type strains of Escherichia coli and Streptococcus pneumoniae have been determined, which revealed that this compound interacts with the enzyme activity for primary sclerosing cholangitis. This nucleoside can also be detected by LC-MS/MS methods and multivariate logistic regression analysis.

Formula: C₁₂H₁₇N₅O₅

Purity: Min. 98 Area-%

Color and Shape: Off-White Powder

Molecular weight: 311.3 g/mol

Ref: 3D-ND05647

N,N-Dimethylguanosine

CAS: 2140-67-2

Formula: C₁₂H₁₇N₅O₅

Purity: 95.0%

Color and Shape: Solid, Crystalline or Powder

Molecular weight: 311.298

Ref: 10-F239106