CAS 2140-71-8

2′-O-Methylguanosine

Description:

2′-O-Methylguanosine is a modified nucleoside that plays a significant role in various biological processes, particularly in RNA metabolism. It consists of a guanine base attached to a ribose sugar, which is further methylated at the 2′ hydroxyl group. This modification is commonly found in tRNA and rRNA, contributing to the stability and functionality of these molecules. The presence of the methyl group enhances the structural integrity of RNA, influencing its folding and interaction with proteins. 2′-O-Methylguanosine is also involved in the regulation of gene expression and can affect the splicing and translation of RNA. Its chemical formula reflects the presence of carbon, hydrogen, nitrogen, and oxygen atoms, characteristic of nucleosides. The compound is soluble in water and exhibits properties typical of nucleosides, such as forming hydrogen bonds and participating in base pairing. Due to its biological significance, 2′-O-Methylguanosine is of interest in research related to RNA biology, therapeutics, and the development of RNA-based drugs.

Formula: C₁₁H₁₅N₅O₅

InChI: InChI=1/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1

InChI key: InChIKey=OVYNGSFVYRPRCG-KQYNXXCUSA-N

SMILES: O(C)[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](CO)[C@H]1O

Synonyms:

• 1-Methylguanosine = 2-O-Methylguanosine
• Guanosine, 2′-O-methyl-
• 2′-O-Methylguanosine
• 2'-O-Methyl-D-guanosine

2'-O-Methylguanosine

CAS: 2140-71-8

Formula: C₁₁H₁₅N₅O₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 297.27

Ref: 3B-M2318

2'-O-Methylguanosine, 99%

CAS: 2140-71-8

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₁H₁₅N₅O₅

Purity: 99%

Molecular weight: 297.27

Ref: 02-J65770

2-Amino-9-((2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methoxytetrahydrofuran-2-Yl)-1H-Purin-6(9H)-One

CAS: 2140-71-8

2-Amino-9-((2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methoxytetrahydrofuran-2-Yl)-1H-Purin-6(9H)-One

Formula: C₁₁H₁₅N₅O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 297.27

Ref: 54-OR1010293

2'-O-Methylguanosine

CAS: 2140-71-8

Formula: C₁₁H₁₅N₅O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 297.2673

Ref: IN-DA00BHLE

2'-OMe-Guanosine

CAS: 2140-71-8

2'-OMe-Guanosine

Formula: C₁₁H₁₅N₅O₅

Purity: ≥98%

Molecular weight: 297.27

Ref: 54-BUP17632

2''-O-Methyl guanosine

CAS: 2140-71-8

Formula: C₁₁H₁₅N₅O₅

Purity: ≥ 98.0%

Color and Shape: White to almost white powder or crystals

Molecular weight: 297.27

Ref: 7W-GC3937

2'-OMe-Guanosine

CAS: 2140-71-8

2'-OMe-Guanosine is a modified nucleoside produced by the action of tRNA guanosine-2'-o-methyltransferase. 2'-OMe-Guanosine has a certain pro-apoptotic effect.

Formula: C₁₁H₁₅N₅O₅

Purity: 99.93% - 99.94%

Color and Shape: White Solid

Molecular weight: 297.27

Ref: TM-T9726

2'-O-Methylguanosine

CAS: 2140-71-8

Formula: C₁₁H₁₅N₅O₅

Molecular weight: 297.27

Ref: 4Z-G-2429

2'-O-Methyl Guanosine

Controlled Product

CAS: 2140-71-8

Applications Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
References Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),

Formula: C₁₁H₁₅N₅O₅

Color and Shape: Neat

Molecular weight: 297.27

Ref: TR-M311825

2'-O-Methylguanosine

CAS: 2140-71-8

2'-O-Methylguanosine is a nucleoside that contains a 2'-O-methyl group at the 2' position of the ribose. It is a component of many nucleic acids and is usually found as a minor component in RNA. 2'-O-Methylguanosine has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase, which may be due to its ability to form hydrogen bonds with the phosphate backbone. This compound has also been shown to act as a competitive inhibitor for both wild-type and mutant bacterial strains, suggesting that it can inhibit DNA synthesis in bacteria by binding to the enzyme's active site. 2'-O-Methylguanosine is present in relatively high concentrations in tissues, such as liver and muscle, where it is involved in metabolism or energy production. The optimum concentration for detection by analytical methods varies depending on the type of detector used.

Formula: C₁₁H₁₅N₅O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 297.27 g/mol

Ref: 3D-NM02941

2'-O-Methylguanosine

CAS: 2140-71-8

2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one

Formula: C₁₁H₁₅N₅O₅

Purity: 98%

Molecular weight: 297.27

Ref: IN-DG19361

2′-O-Methylguanosine

CAS: 2140-71-8

Formula: C₁₁H₁₅N₅O₅

Purity: 98%

Color and Shape: Solid, White to almost white powder

Molecular weight: 297.271

Ref: 10-F225192

2'-O-Methyl Guanosine-d3

Controlled Product

CAS: 2140-71-8

Applications 2'-O-Methyl Guanosine-d3 is a labeled analogue of 2'-O-Methyl Guanosine (M311825), which is a Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
References Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),

Formula: C₁₁D₃H₁₂N₅O₅

Color and Shape: Neat

Molecular weight: 300.29

Ref: TR-M311827