CAS 21738-42-1

Oxamniquine

Description:

Oxamniquine is a synthetic compound primarily used as an anthelmintic agent, particularly effective against schistosomiasis, a disease caused by parasitic worms. It is classified as a quinoline derivative and exhibits a unique mechanism of action that involves the disruption of the parasite's metabolism and reproductive capabilities. The chemical structure of oxamniquine includes a quinoline ring, which contributes to its biological activity. It is typically administered orally and is known for its moderate solubility in water, which can influence its bioavailability. Oxamniquine is metabolized in the liver, and its pharmacokinetics can be affected by various factors, including the presence of food and individual patient characteristics. While generally well-tolerated, it may cause side effects such as gastrointestinal disturbances or allergic reactions in some individuals. Due to its specific action against schistosomes, oxamniquine plays a crucial role in public health initiatives aimed at controlling and eliminating schistosomiasis in endemic regions.

Formula: C₁₄H₂₁N₃O₃

InChI: InChI=1S/C14H21N3O3/c1-9(2)15-7-12-4-3-10-5-11(8-18)14(17(19)20)6-13(10)16-12/h5-6,9,12,15-16,18H,3-4,7-8H2,1-2H3

InChI key: InChIKey=XCGYUJZMCCFSRP-UHFFFAOYSA-N

SMILES: N(=O)(=O)C=1C=C2C(=CC1CO)CCC(CNC(C)C)N2

Synonyms:

• (.+-.)-Oxamniquine
• 1,2,3,4-Tetrahydro-2-[[(1-methylethyl)amino]methyl]-7-nitro-6-quinolinemethanol
• 1,2,3,4-Tetrahydro-6-(hydroxymethyl)-2-[(isopropylamino)methyl]-7-nitroquinoline
• 6-Hydroxymethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetrahydroquinoline
• 6-Quinolinemethanol, 1,2,3,4-tetrahydro-2-[(isopropylamino)methyl]-7-nitro-
• Mansil
• Nsc 352888
• Oxamnichin
• Oxamniquina
• Uk 4261
• Uk 4271
• Vansil

Oxamniquine

CAS: 21738-42-1

Oxamniquine is an effective compound for the treatment of schistosomiasis.

Formula: C₁₄H₂₁N₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 279.33

Ref: TM-T16416