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CAS 21829-25-4

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Nifedipine

Description:
Nifedipine is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of medications and works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced myocardial oxygen demand. Nifedipine is typically administered in its extended-release form to provide sustained therapeutic effects. The substance is characterized by its yellow crystalline appearance and is relatively lipophilic, which influences its absorption and distribution in the body. It has a moderate solubility in water and is often formulated with various excipients to enhance its bioavailability. Nifedipine can cause side effects such as flushing, headache, and peripheral edema, and its use may be contraindicated in certain populations, such as those with severe hypotension or certain types of heart conditions. As with any medication, it is essential to use nifedipine under medical supervision to monitor for efficacy and potential adverse effects.
Formula:C17H18N2O6
InChI:InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
InChI key:InChIKey=HYIMSNHJOBLJNT-UHFFFAOYSA-N
SMILES:C(OC)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C2=C(N(=O)=O)C=CC=C2
Synonyms:
  • 2,6-Dimethyl-3,5-dicarbomethoxy-4-(2-nitrophenyl)-1,4-dihydropyridine
  • 4-(2-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine
  • Adalat
  • Adalate
  • Adapine
  • Adapress
  • Alat
  • Aldipin
  • Alfadat
  • Alonix
  • See more synonyms
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