CAS 218600-44-3

2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid

Description:

2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid, with the CAS number 218600-44-3, is a synthetic compound derived from oleanolic acid, a triterpenoid found in various plants. This compound features a cyano group and two carbonyl groups, contributing to its unique reactivity and potential biological activity. It is characterized by its complex structure, which includes a pentacyclic triterpene framework. The presence of the cyano group may enhance its ability to interact with biological targets, making it of interest in medicinal chemistry. The dioxo functionality suggests potential for various chemical transformations, which could be exploited in synthetic applications. Additionally, compounds of this class have been studied for their anti-inflammatory, anticancer, and antimicrobial properties. However, detailed studies on its specific biological activities and mechanisms of action are necessary to fully understand its potential applications in pharmaceuticals or other fields. As with many synthetic compounds, safety and toxicity assessments are crucial for any practical use.

Formula: C₃₁H₄₁NO₄

InChI: InChI=1/C31H41NO4/c1-26(2)10-12-31(25(35)36)13-11-30(7)23(19(31)16-26)20(33)14-22-28(5)15-18(17-32)24(34)27(3,4)21(28)8-9-29(22,30)6/h14-15,19,21,23H,8-13,16H2,1-7H3,(H,35,36)/t19-,21-,23-,28-,29+,30+,31-/m0/s1

Synonyms:

• 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid

2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid

CAS: 218600-44-3

Formula: C₃₁H₄₁NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 491.6615

Ref: IN-DA00BEQL

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6A,6B,9,9,12A-Heptamethyl-10,14-Dioxo-1,3,4,5,6,6A,6B,7,8,8A,9,10,12A,14,14A,14B-Hexadecahydropicene-4A(2H)-Carboxylic Acid

CAS: 218600-44-3

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6A,6B,9,9,12A-Heptamethyl-10,14-Dioxo-1,3,4,5,6,6A,6B,7,8,8A,9,10,12A,14,14A,14B-Hexadecahydropicene-4A(2H)-Carboxylic Acid

Purity: 98%

Molecular weight: 491.66g/mol

Ref: 54-OR1026212

Bardoxolone

CAS: 218600-44-3

Bardoxolone

Purity: ≥95%

Molecular weight: 491.66g/mol

Ref: 54-BUP13324

Bardoxolone

CAS: 218600-44-3

Bardoxolone (CDDO) inhibits iNOS, COX-2 in cells; IC50=0.4nM. Reduces ROS/RNS, DNA damage, & cancer growth; triggers apoptosis & boosts antioxidant genes.

Formula: C₃₁H₄₁NO₄

Purity: 97.9% - 98.97%

Color and Shape: Solid

Molecular weight: 491.66

Ref: TM-T2915

Bardoxolone

Controlled Product

CAS: 218600-44-3

Applications Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events.
References Shepler, B., et al.: Clinical. Therap., 34, 1237 (2012); Speranza, G., et al.: Cancer. Chemo. Pharmacol., 69, 431 (2012); Sporn, M.B., et al.: J. Natural. Prod., 74, 537 (2011);

Formula: C₃₁H₄₁NO₄

Color and Shape: Neat

Molecular weight: 491.66

Ref: TR-B118660

Bardoxolone

CAS: 218600-44-3

Bardoxolone methyl is a novel compound that has been shown to be a potent inducer of erythropoietin. It is also an inhibitor of the transcriptional factor, nuclear factor-κB (NF-κB), and it has been shown to have potent anti-inflammatory effects in vitro. In vivo studies have demonstrated that bardoxolone methyl significantly reduces the incidence and severity of bowel disease in a rat model. The drug also inhibits cardiac fibrosis and heart failure in rats with chronic kidney disease. Finally, bardoxolone methyl has been shown to increase natriuretic peptide levels in both mice and humans.

Formula: C₃₁H₄₁NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 491.66 g/mol

Ref: 3D-FB30002