CAS 218600-53-4

2-Cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid methyl ester

Description:

2-Cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid methyl ester, with CAS number 218600-53-4, is a synthetic compound belonging to the class of oleanane triterpenoids. This substance is characterized by its complex molecular structure, which includes a cyano group and two dioxole rings, contributing to its unique chemical properties. It typically exhibits a high degree of stability due to its rigid framework, making it resistant to various chemical reactions. The presence of the cyano group enhances its reactivity, allowing for potential applications in organic synthesis and medicinal chemistry. Additionally, the methyl ester functional group can influence its solubility and bioavailability, making it a subject of interest in pharmacological studies. This compound has been investigated for its potential biological activities, including anti-inflammatory and anticancer properties, although further research is necessary to fully elucidate its mechanisms of action and therapeutic potential. Overall, 2-Cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid methyl ester represents a fascinating area of study within the field of natural product chemistry and drug development.

Formula: C₃₂H₄₃NO₄

InChI: InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1

InChI key: InChIKey=WPTTVJLTNAWYAO-KPOXMGGZSA-N

SMILES: C(OC)(=O)[C@]12[C@]([C@@]3([C@@](C)(CC1)[C@@]4(C)C(=CC3=O)[C@]5(C)[C@@](CC4)(C(C)(C)C(=O)C(C#N)=C5)[H])[H])(CC(C)(C)CC2)[H]

Synonyms:

• (4aS,6aR,6bS,8aR,12aS,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate
• (6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxylic acid methyl ester
• 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
• 2-Cyano-3,12-dioxoolen-1,9-dien-28-oic acid methyl ester
• Bardoxolone methyl
• CDDO-Me
• Cddo-Methyl Ester
• Dcl 000217
• Methyl 2-Cyano-3,12-Dioxooleana-1,9(11)-Dien-28-Oate
• NSC 713200
• Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester
• Rta 402
• Tp-155C
• TP-155
• (4aS,6aR,6bS,8aR,12aS,14bS)-Methyl 11-cyano-2,2,6a,6b,9,9,12a-he
• Bardoxolone Me ester
• (4aR,6aR,6bS,8aR,12aR,14bR)-Methyl 11-cyano-2,2,6a,6b,9,9,12a-heptaMethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate
• Bardoxolone Methyl (RTA 402)

Bardoxolone Methyl

CAS: 218600-53-4

Formula: C₃₂H₄₃NO₄

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 505.70

Ref: 3B-B6838

Bardoxolone Methyl

CAS: 218600-53-4

Bardoxolone Methyl

Formula: C₃₂H₄₃NO₄

Purity: >98%

Molecular weight: 505.69

Ref: 54-OR1025712

Bardoxolone Methyl

CAS: 218600-53-4

Bardoxolone Methyl

Formula: C₃₂H₄₃NO₄

Purity: 99.5%

Color and Shape: Solid

Molecular weight: 505.69

Ref: 54-BUP15732

CDDO Methyl Ester

Controlled Product

CAS: 218600-53-4

Applications CDDO Methyl Ester is a synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. CDDO Methyl Ester is a novel therapeutic agent in the treatment of acute myeloid leukemia and in the treatment of pancreatic cancer as well as other forms of cancer.
References Shishodia, S. et al.: Clin. Cancer Res., 12, 1828 (2006); Konopleva, M. et al.: Leukemia, 19, 1350 (2005); Deeb, D. et al.: Cancers, 2, 1779 (2010); Gao, X. et al.: J. Exp. Therap. Oncol., 9, 119 (2011);

Formula: C₃₂H₄₃NO₄

Color and Shape: Neat

Molecular weight: 505.69

Ref: TR-C228100

Methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxylate

CAS: 218600-53-4

Methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxylate

Formula: C₃₂H₄₃NO₄

Purity: 98%

Molecular weight: 505.69

Ref: IN-DG217116

Bardoxolone Methyl

CAS: 218600-53-4

Formula: C₃₂H₄₃NO₄

Molecular weight: 505.70

Ref: 4Z-B-277001

Bardoxolone Methyl

CAS: 218600-53-4

Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-

Formula: C₃₂H₄₃NO₄

Purity: 97.81% - 99.96%

Color and Shape: Solid

Molecular weight: 505.6881

Ref: TM-T6165

Bardoxolone methyl

CAS: 218600-53-4

Activater of the Nrf2 pathway and an inhibitor of the NF-κB pathway.  Possible applications have extended to anti-viral treatment of COVID-19.

Formula: C₃₂H₄₃NO₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 505.69 g/mol

Ref: 3D-FB15804

Bardoxolone methyl

CAS: 218600-53-4

Formula: C₃₂H₄₃NO₄

Purity: 98%

Molecular weight: 505.699

Ref: 10-F361926

Bardoxolone methyl

CAS: 218600-53-4

Formula: C₃₂H₄₃NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 505.6881

Ref: IN-DA006Z02