CAS 21881-77-6

m-Nifedipine

Description:

m-Nifedipine, also known as 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester, is a calcium channel blocker primarily used in the treatment of hypertension and angina. It belongs to the dihydropyridine class of medications, which work by inhibiting calcium ions from entering vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced blood pressure. The compound is characterized by its yellow crystalline appearance and is typically administered in oral form. Its mechanism of action involves selective inhibition of L-type calcium channels, which helps to relax blood vessels and improve blood flow. m-Nifedipine is known for its rapid onset of action and relatively short half-life, necessitating multiple doses throughout the day for sustained therapeutic effect. Additionally, it may have side effects such as headache, flushing, and peripheral edema. As with any medication, it is important to consider contraindications and potential interactions with other drugs.

Formula: C₁₇H₁₈N₂O₆

InChI: InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-6-5-7-12(8-11)19(22)23/h5-8,15,18H,1-4H3

InChI key: InChIKey=MCTRZKAKODSRLQ-UHFFFAOYSA-N

SMILES: C(OC)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2

Synonyms:

• 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
• 3,5-Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3,5-dimethyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, dimethyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-, dimethyl ester
• BAY-a 4339
• Dimethyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
• Dimethyl 4-(m-nitrophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
• m-Nifedipine

Nicardipine Related Compound C (Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate)

CAS: 21881-77-6

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₇H₁₈N₂O₆

Color and Shape: Pale Yellow Solid

Molecular weight: 346.33

Ref: 45-1463268

m-Nifedipine

CAS: 21881-77-6

Formula: C₁₇H₁₈N₂O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 346.3346

Ref: IN-DA003S4X

M-Nifedipine

CAS: 21881-77-6

M-Nifedipine

Purity: 98%

Molecular weight: 346.33g/mol

Ref: 54-OR1030334

Nicardipine EP Impurity C (Nicardipine USP Related Compound C, Nitrendipine EP Impurity B)

CAS: 21881-77-6

Formula: C₁₇H₁₈N₂O₆

Color and Shape: Pale Yellow Solid

Molecular weight: 346.34

Ref: 4Z-N-4820

m-Nifedipine

CAS: 21881-77-6

m-Nifedipine, an impurity of Nifedipine, serves as a potent calcium channel blocker and the preferred treatment option for cardiac insufficiencies.

Formula: C₁₇H₁₈N₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 346.33

Ref: TM-T11926

Dimethyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Controlled Product

CAS: 21881-77-6

Formula: C₁₇H₁₈N₂O₆

Color and Shape: Neat

Molecular weight: 346.33

Ref: 86-MM0092.01

M-NIFEDIPINE

Controlled Product

CAS: 21881-77-6

Impurity Nicardipine USP Related Compound C
Applications m-Nifedipine is an impurity of Nifedipine (N457000). Nicardipine USP Related Compound C.
References Gao, Y., et al.: Chin. J. Pharmacol. Toxicol., 4, 21 (1990), Ikegaya, H., et al.: Forensic Sci. Int., 130, 25 (2002), van Eeckhaut, A., et al.: J. Pharm. Biomed. Anal., 36, 799 (2004), Jing, X., et al.: Chin J. Pharm., 39, 125 (2008),

Formula: C₁₇H₁₈N₂O₆

Color and Shape: Light Yellow

Molecular weight: 346.33

Ref: TR-N457015

Nicardipine USP Related Compound C

CAS: 21881-77-6

Formula: C₁₇H₁₈N₂O₆

Molecular weight: 346.34

Ref: ST-EA-CP-N7004

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester

CAS: 21881-77-6

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester is a creatine kinase inhibitor that blocks the synthesis of creatine phosphate, which is an important energy source for muscle contraction. Creatine kinase inhibitors are used in the treatment of congestive heart failure and myocardial infarct. They also have vasodilatory effects on blood vessels and can be used to treat hypertension. The elimination rate of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester depends on its formulation: solid dispersions have a half life of about 3 hours whereas orally administered doses have a half life of about 8 hours.

Formula: C₁₇H₁₈N₂O₆

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 346.33 g/mol

Ref: 3D-ID57942

Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

CAS: 21881-77-6

Purity: 95%

Molecular weight: 346.339

Ref: 10-F981109