CAS 21881-77-6
:m-Nifedipine
Description:
m-Nifedipine, also known as 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester, is a calcium channel blocker primarily used in the treatment of hypertension and angina. It belongs to the dihydropyridine class of medications, which work by inhibiting calcium ions from entering vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced blood pressure. The compound is characterized by its yellow crystalline appearance and is typically administered in oral form. Its mechanism of action involves selective inhibition of L-type calcium channels, which helps to relax blood vessels and improve blood flow. m-Nifedipine is known for its rapid onset of action and relatively short half-life, necessitating multiple doses throughout the day for sustained therapeutic effect. Additionally, it may have side effects such as headache, flushing, and peripheral edema. As with any medication, it is important to consider contraindications and potential interactions with other drugs.
Formula:C17H18N2O6
InChI:InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-6-5-7-12(8-11)19(22)23/h5-8,15,18H,1-4H3
InChI key:InChIKey=MCTRZKAKODSRLQ-UHFFFAOYSA-N
SMILES:C(OC)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2
Synonyms:- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
- 3,5-Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3,5-dimethyl ester
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, dimethyl ester
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-, dimethyl ester
- BAY-a 4339
- Dimethyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
- Dimethyl 4-(m-nitrophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
- m-Nifedipine
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Found 10 products.
Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS:Purity:95%Molecular weight:346.339Nicardipine Related Compound C (Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate)
CAS:Compounds containing an unfused pyridine ring in the structure, nesoiFormula:C17H18N2O6Color and Shape:Pale Yellow SolidMolecular weight:346.11649Nicardipine EP Impurity C (Nicardipine USP Related Compound C, Nitrendipine EP Impurity B)
CAS:Formula:C17H18N2O6Color and Shape:Pale Yellow SolidMolecular weight:346.34m-Nifedipine
CAS:m-Nifedipine, an impurity of Nifedipine, serves as a potent calcium channel blocker and the preferred treatment option for cardiac insufficiencies.Formula:C17H18N2O6Purity:98%Color and Shape:SolidMolecular weight:346.33Dimethyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS:Controlled ProductFormula:C17H18N2O6Color and Shape:NeatMolecular weight:346.33M-NIFEDIPINE
CAS:Controlled ProductImpurity Nicardipine USP Related Compound C
Applications m-Nifedipine is an impurity of Nifedipine (N457000). Nicardipine USP Related Compound C.
References Gao, Y., et al.: Chin. J. Pharmacol. Toxicol., 4, 21 (1990), Ikegaya, H., et al.: Forensic Sci. Int., 130, 25 (2002), van Eeckhaut, A., et al.: J. Pharm. Biomed. Anal., 36, 799 (2004), Jing, X., et al.: Chin J. Pharm., 39, 125 (2008),Formula:C17H18N2O6Color and Shape:NeatMolecular weight:346.331,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester
CAS:1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester is a creatine kinase inhibitor that blocks the synthesis of creatine phosphate, which is an important energy source for muscle contraction. Creatine kinase inhibitors are used in the treatment of congestive heart failure and myocardial infarct. They also have vasodilatory effects on blood vessels and can be used to treat hypertension. The elimination rate of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester depends on its formulation: solid dispersions have a half life of about 3 hours whereas orally administered doses have a half life of about 8 hours.Formula:C17H18N2O6Purity:Min. 95%Color and Shape:Yellow PowderMolecular weight:346.33 g/mol
