CAS 219911-35-0

Pyridine, 2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1)

Description:

Pyridine, 2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1) is a chemical compound characterized by its pyridine ring structure, which is a six-membered aromatic ring containing one nitrogen atom. This compound features a methyl group and a phenylethynyl substituent at specific positions on the pyridine ring, contributing to its unique chemical properties. As a hydrochloride salt, it is typically encountered in a solid form, which enhances its solubility in polar solvents, particularly water. The presence of the nitrogen atom in the pyridine ring imparts basicity, allowing it to participate in various chemical reactions, including nucleophilic substitutions and coordination with metal ions. This compound may exhibit biological activity, making it of interest in pharmaceutical research. Its molecular structure suggests potential applications in organic synthesis and material science. Safety data should be consulted for handling, as with all chemical substances, to ensure proper precautions are taken due to potential toxicity or reactivity.

Formula: C₁₄H₁₁N·ClH

InChI: InChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H

InChI key: InChIKey=PKDHDJBNEKXCBI-UHFFFAOYSA-N

SMILES: C(#CC1=CC=CC=C1)C=2N=C(C)C=CC2.Cl

Synonyms:

• 2-Methyl-6-(phenylethynyl)pyridine hydrochloride
• MPEP hydrochloride
• Pyridine, 2-Methyl-6-(2-Phenylethynyl)-
• Pyridine, 2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1)
• Pyridine, 2-methyl-6-(phenylethynyl)-, hydrochloride
• Pyridine, 6-methyl-2-(phenylethynyl)-
• 2-Methyl-6-(phenylethynyl)pyridine

MPEP Hydrochloride

CAS: 219911-35-0

Formula: C₁₄H₁₂ClN

Purity: 98%

Color and Shape: Solid

Molecular weight: 229.7048

Ref: IN-DA00BEB2

MPEP hydrochloride

CAS: 219911-35-0

MPEP hydrochloride

Purity: ≥98%

Molecular weight: 229.7g/mol

Ref: 54-BUP06879

6-Methyl-2-(phenylethynyl)pyridine hydrochloride

CAS: 219911-35-0

Formula: C₁₄H₁₁N·HCl

Molecular weight: 229.70

Ref: 7W-GK5831

MPEP hydrochloride

CAS: 219911-35-0

MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).

Formula: C₁₄H₁₂ClN

Purity: 99.87% - >99.99%

Color and Shape: Solid

Molecular weight: 229.7

Ref: TM-T2497

MPEP Hydrochloride

Controlled Product

CAS: 219911-35-0

Stability Light Sensitive
Applications MPEP is a potent and highly selective non-competitive mGlu5a receptor antagonist (1,2). It is also a positive allosteric modulator at mGlu4 receptors.MPEP exhibits anxiolytic and antidepressant properties that may be applicable for treating schizophrenia (3).
References (1) Latif-Hemandez, A., et al.: Front Cell Neurosci. 10, 252 (2016)(2) Hikichi, H. et al.: Eur. J. Pharmacol., 639, 99 (2010)(3) Inta, I., et al.: Pharmacopsychiatry. 49, 142 (2016)

Formula: C₁₄H₁₂ClN

Color and Shape: Neat

Molecular weight: 229.7

Ref: TR-M745805

2-Methyl-6-(phenylethynyl)pyridine HCl

CAS: 219911-35-0

2-Methyl-6-(phenylethynyl)pyridine (MPEP) is a drug that is used in the treatment of Parkinson's disease. This drug inhibits the synthesis of proteins, including glutamate and dopamine, which are involved in Parkinson's disease. MPEP has been shown to be effective against Parkinson's disease by blocking protein synthesis in the caudate putamen and other brain regions. It also lowers locomotor activity and improves motor skills in rats. MPEP binds to response element-binding protein (RBP), which is involved in the regulation of gene expression. The binding of MPEP to RBP leads to an increase in levels of endogenous adenosine, which blocks the effects of dopamine and serotonin on postsynaptic neurons.

Formula: C₁₄H₁₁N·HCl

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 229.7 g/mol

Ref: 3D-FM64915