CAS 220038-19-7

(5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,10,11,12,13,15,16-decahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one

Description:

The chemical substance with the name "(5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,10,11,12,13,15,16-decahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one" and CAS number "220038-19-7" is a complex organic compound characterized by its intricate polycyclic structure and multiple functional groups. It features a tricyclic core with various stereocenters, indicating specific spatial arrangements that can influence its biological activity. The presence of methoxy and methylamino groups suggests potential for interactions with biological targets, possibly contributing to pharmacological properties. The compound's epoxy and triazole functionalities may also enhance its reactivity and solubility in various solvents. Given its structural complexity, this substance may exhibit unique chemical behavior, making it of interest in medicinal chemistry and drug development. Its specific stereochemistry and functional groups could play crucial roles in determining its efficacy and safety profiles in biological systems.

Formula: C₂₈H₃₀N₄O₃

InChI: InChI=1/C28H30N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h5,7,9,11,17,20,26,29H,4,6,8,10,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1

1,2,3,4-Tetrahydro Staurosporin

Controlled Product

CAS: 220038-19-7

Applications Staurosporine derivative for use as isoenzyme PKCα inhibitors and anticancer agents.
References Pollack, V., et al.: J. Pharmacol. Exp. Ther., 291, 739 (1999), Barker, A., et al.: Bioorg. Med. Chem. Lett., 11, 1911 (2001), Brignola, P., et al.: J. Biol. Chem., 277, 1576 (2002), Amann, J., et al.: Cancer Res., 65, 226 (2005), Zhang, X., et al.: Cell, 125, 1137 (2006),

Formula: C₂₈H₂₆N₄O₃

Color and Shape: Neat

Molecular weight: 466.53

Ref: TR-T295700

AFN941

CAS: 220038-19-7

AFN941 is a staurosporine analog, acting as a Jak3-specific inhibitor.

Formula: C₂₈H₃₀N₄O₃

Color and Shape: Solid

Molecular weight: 470.56

Ref: TM-T69812