CAS 220127-57-1

Imatinib mesylate

Description:

Imatinib mesylate is a targeted therapy medication primarily used in the treatment of certain types of cancer, particularly chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs). It functions as a tyrosine kinase inhibitor, specifically targeting the BCR-ABL fusion protein that is often present in CML. The chemical formula for imatinib mesylate is C29H31N7O2S, and it is characterized by its ability to selectively inhibit the activity of specific kinases involved in cell proliferation and survival. This selective inhibition helps to reduce the growth of cancer cells while sparing normal cells, leading to fewer side effects compared to traditional chemotherapy. Imatinib mesylate is typically administered orally and is known for its relatively good bioavailability. The mesylate salt form enhances its solubility and stability. Common side effects may include nausea, fatigue, and fluid retention, but overall, it has significantly improved the prognosis for patients with the conditions it treats.

Formula: C₂₉H₃₁N₇O·CH₄O₃S

InChI: InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)

InChI key: InChIKey=YLMAHDNUQAMNNX-UHFFFAOYSA-N

SMILES: N(C=1N=C(C=CN1)C=2C=CC=NC2)C3=CC(NC(=O)C4=CC=C(CN5CCN(C)CC5)C=C4)=CC=C3C.S(C)(=O)(=O)O

Synonyms:

• 1-Methyl-4-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)piperazine methanesulfonate
• 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide monomethanesulfonate
• 4-[(4-Methylpiperazin-1-Yl)Methyl]-N-[4-Methyl-3-[(4-Pyridin-3-Ylpyrimidin-2-Yl)Amino]Phenyl]Benzamide Methanesulfonate
• Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:1)
• Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, monomethanesulfonate
• Cgp 57148B
• Gleevac
• Gleevec
• Glivec
• Imatinib Mesilate
• Imatinib Methanesulfonate
• Imatinib mesylate(Alpha form)
• Imatinibmesylate
• Mitinab
• St 571
• Sti 571

Imatinib

CAS: 152459-95-5, 220127-57-1

Formula: C₂₉H₃₁N₇O

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 493.62

Ref: 3B-I0906

IMATINIB MESILATE CRS

CAS: 220127-57-1

IMATINIB MESILATE CRS

Formula: C₂₉H₃₁N₇O

Color and Shape: White. Whitish. Light Brown. Slightly Yellow. Powder., White. Whitish. Light Brown. Slightly Yellow. Powder.

Molecular weight: 493.6027

Ref: 41-Y0001691

IMATINIB FOR SYSTEM SUITABILITY CRS

CAS: 220127-57-1

IMATINIB FOR SYSTEM SUITABILITY CRS

Formula: C₂₉H₃₁N₇O

Color and Shape: White. Whitish. Light Brown. Slightly Yellow. Powder., White. Whitish. Light Brown. Slightly Yellow. Powder.

Molecular weight: 493.6027

Ref: 41-Y0001692

Imatinib impurity standard

CAS: 220127-57-1, 404844-02-6, 571186-93-1

Imatinib impurity standard

Color and Shape: Off-White

Ref: 47-1303

Imatinib mesilate

CAS: 220127-57-1

Imatinib mesilate

Formula: C₃₀H₃₅N₇SO₄

Purity: 99.7%

Color and Shape: White

Molecular weight: 589.24712

Ref: 47-1302

Imatinib mesylate

CAS: 220127-57-1

Formula: C₃₀H₃₅N₇O₄S

Purity: 99%

Color and Shape: Solid

Molecular weight: 589.7084

Ref: IN-DA00350I

Imatinib Mesylate

CAS: 220127-57-1

Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR,

Formula: C₂₉H₃₁N₇O·CH₄SO₃

Purity: 98% - >99.99%

Color and Shape: White Crystalline Powder

Molecular weight: 589.71

Ref: TM-T1621

Imatinib mesylate

CAS: 220127-57-1

Formula: C₂₉H₃₁N₇O·CH₄O₃S

Purity: 98.0 - 102.0 %

Color and Shape: White to off-white, light brown or light yellow powder

Molecular weight: 589.71

Ref: 7W-GP4375

Imatinib Mesylate

CAS: 220127-57-1

Imatinib Mesylate

Purity: ≥98%

Molecular weight: 589.71g/mol

Ref: 54-BUP17694

Imatinib Mesylate

CAS: 220127-57-1

Formula: C₂₉H₃₁N₇O·CH₄O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 493.62 96.11

Ref: 4Z-I-097

Imatinib Methanesulphonate Salt

CAS: 220127-57-1

Imatinib Methanesulphonate Salt

Formula: C₂₉H₃₁N₇O·CH₃SO₃H

Purity: 99+% (nmr) (Typical Value in Batch COA)

Color and Shape: solid

Molecular weight: 589.71g/mol

Ref: 54-BIFK0026

Imatinib Mesilate

Controlled Product

CAS: 220127-57-1

Formula: C₂₉H₃₁N₇O·CH₄O₃S

Color and Shape: Neat

Molecular weight: 589.71

Ref: 86-MM3566.00

Imatinib Mesylate

CAS: 152459-95-5, 220127-57-1

Formula: C₂₉H₃₁N₇O·CH₄O₃S

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 589.72

Ref: 3B-I0936

Imatinib RC11

Controlled Product

CAS: 220127-57-1

Formula: C₃₃H₂₈N₁₀O

Color and Shape: Neat

Molecular weight: 580.642

Ref: TR-I121910

Gleevec (Imatinib Mesylate)

Controlled Product

CAS: 220127-57-1

Applications A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.
References Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),

Formula: C₂₉H₃₁N₇O·CH₄O₃S

Color and Shape: White

Molecular weight: 589.71

Ref: TR-G407000

Imatinib mesylate

CAS: 220127-57-1

BCR-ABL1 kinase inhibitor; neoadjuvant

Formula: C₂₉H₃₁N₇O·CH₄O₃S

Purity: Min. 97.5 Area-%

Color and Shape: Powder

Molecular weight: 589.71 g/mol

Ref: 3D-FI10812

Imatinib mesylate - Bio-X ™

CAS: 220127-57-1

Imatinib is a tyrosine kinase inhibitor drug that is used for the treatment of various leukaemias, gastrointestinal stromal tumours and myeloproliferative disease. This drug inhibits the BCR-ABL tyrosine kinase and thus prevents the downstream phosphorylation of target proteins. This drug also inhibits PDGF, SCF and c-kit.

Formula: C₂₉H₃₁N₇O·CH₄O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 589.71 g/mol

Ref: 3D-BI164678

Imatinib methanesulfonate

CAS: 220127-57-1

Formula: C₃₀H₃₅N₇O₄S

Purity: 95%

Color and Shape: Solid

Molecular weight: 589.72

Ref: 10-M06311