CAS 220127-57-1: Imatinib mesylate

Description: Imatinib mesylate is a targeted therapy medication primarily used in the treatment of certain types of cancer, particularly chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs). It functions as a tyrosine kinase inhibitor, specifically targeting the BCR-ABL fusion protein that is often present in CML. The chemical formula for imatinib mesylate is C29H31N7O2S, and it is characterized by its ability to selectively inhibit the activity of specific kinases involved in cell proliferation and survival. This selective inhibition helps to reduce the growth of cancer cells while sparing normal cells, leading to fewer side effects compared to traditional chemotherapy. Imatinib mesylate is typically administered orally and is known for its relatively good bioavailability. The mesylate salt form enhances its solubility and stability. Common side effects may include nausea, fatigue, and fluid retention, but overall, it has significantly improved the prognosis for patients with the conditions it treats.

Formula: C₂₉H₃₁N₇O·CH₄O₃S

InChI: InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)

InChI key: InChIKey=YLMAHDNUQAMNNX-UHFFFAOYSA-N

SMILES: O=C(NC1=CC=C(C(=C1)NC=2N=CC=C(N2)C3=CN=CC=C3)C)C4=CC=C(C=C4)CN5CCN(C)CC5.O=S(=O)(O)C

Synonyms:

• 1-Methyl-4-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)piperazine methanesulfonate
• 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide monomethanesulfonate
• 4-[(4-Methylpiperazin-1-Yl)Methyl]-N-[4-Methyl-3-[(4-Pyridin-3-Ylpyrimidin-2-Yl)Amino]Phenyl]Benzamide Methanesulfonate
• Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:1)
• Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, monomethanesulfonate
• Cgp 57148B
• Gleevac
• Gleevec
• Glivec
• Imatinib Mesilate
• Imatinib Methanesulfonate
• Imatinib mesylate(Alpha form)
• Imatinibmesylate
• Mitinab
• St 571
• Sti 571
• Imatinib mesylate

Imatinib Mesylate

CAS: 152459-95-5 220127-57-1

• Formula: C₂₉H₃₁N₇O·CH₄O₃S
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 589.72

Imatinib

CAS: 152459-95-5 220127-57-1

• Formula: C₂₉H₃₁N₇O
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow to Light orange powder to crystal
• Molecular weight: 493.62

Imatinib methanesulfonate

CAS: 220127-57-1

• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 589.719970703125

Imatinib mesilate CRS

CAS: 220127-57-1

• Formula: C₂₉H₃₁N₇O
• Color and Shape: White. Whitish. Light Brown. Slightly Yellow. Powder., White. Whitish. Light Brown. Slightly Yellow. Powder.
• Molecular weight: 493.6027

Imatinib impurity standard

CAS: 220127-57-1404844-02-6 571186-93-1

• Color and Shape: Off-White

Imatinib mesilate

CAS: 220127-57-1

• Formula: C₃₀H₃₅N₇SO₄
• Purity: 99.7%
• Color and Shape: White
• Molecular weight: 589.24712

Imatinib for system suitability CRS

CAS: 220127-57-1

• Formula: C₂₉H₃₁N₇O
• Color and Shape: White. Whitish. Light Brown. Slightly Yellow. Powder., White. Whitish. Light Brown. Slightly Yellow. Powder.
• Molecular weight: 493.6027

Imatinib Mesylate

CAS: 220127-57-1

Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, …

• Formula: C₂₉H₃₁N₇O·CH₄SO₃
• Purity: 100% - 99.97%
• Color and Shape: White Crystalline Powder
• Molecular weight: 589.71

Imatinib mesylate

CAS: 220127-57-1

• Formula: C₃₀H₃₅N₇O₄S
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 589.7084

Imatinib Mesylate

CAS: 220127-57-1

• Purity: ≥98%
• Molecular weight: 589.71g/mol

Imatinib mesylate

CAS: 220127-57-1

• Formula: C₂₉H₃₁N₇O·CH₄O₃S
• Purity: 98.0 - 102.0 %
• Color and Shape: White to off-white, light brown or light yellow powder
• Molecular weight: 589.71

Imatinib Mesylate

CAS: 220127-57-1

• Formula: C₂₉H₃₁N₇O·CH₄O₃S
• Color and Shape: White To Off-White Solid
• Molecular weight: 493.62 96.11

Imatinib Methanesulphonate Salt

CAS: 220127-57-1

• Formula: C₂₉H₃₁N₇O·CH₃SO₃H
• Purity: 99+% (nmr) (Typical Value in Batch COA)
• Color and Shape: solid
• Molecular weight: 589.71g/mol

Imatinib Mesilate

CAS: 220127-57-1

• Formula: C₂₉H₃₁N₇O·CH₄O₃S
• Color and Shape: Neat
• Molecular weight: 589.71

Imatinib mesylate, 98%

CAS: 220127-57-1

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₃₀H₃₅N₇O₄S
• Purity: 98%
• Color and Shape: White to light yelow or light beige, Powder
• Molecular weight: 589.72

Gleevec (Imatinib Mesylate)

CAS: 220127-57-1

Applications A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous …

• Formula: C₂₉H₃₁N₇O·CH₄O₃S
• Color and Shape: White
• Molecular weight: 589.71

Imatinib mesylate - Bio-X ™

CAS: 220127-57-1

Imatinib is a tyrosine kinase inhibitor drug that is used for the treatment of various …

• Formula: C₂₉H₃₁N₇O·CH₄O₃S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 589.71 g/mol

Imatinib mesylate

CAS: 220127-57-1

BCR-ABL1 kinase inhibitor; neoadjuvant

• Formula: C₂₉H₃₁N₇O·CH₄O₃S
• Purity: Min. 97.5 Area-%
• Color and Shape: Powder
• Molecular weight: 589.71 g/mol

Imatinib RC11

CAS: 220127-57-1

• Formula: C₃₃H₂₈N₁₀O
• Color and Shape: Neat
• Molecular weight: 580.642