CAS 220644-02-0

N-[(benzyloxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-L-alaninamide

Description:

N-[(benzyloxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-L-alaninamide, with the CAS number 220644-02-0, is a synthetic compound that belongs to the class of amino acid derivatives. This substance features a complex structure characterized by the presence of a benzyloxycarbonyl group, which is a common protecting group in peptide synthesis, and a fluoro-substituted propyl moiety that may impart unique biological properties. The compound contains two amino acid residues, L-valine and L-alanine, which contribute to its potential as a peptide or peptide-like molecule. Its carboxymethyl and fluoro groups suggest possible applications in medicinal chemistry, particularly in the development of pharmaceuticals with enhanced bioactivity or specificity. The presence of multiple functional groups indicates that it may participate in various chemical reactions, making it a versatile candidate for further research in drug design and development. As with many synthetic compounds, its stability, solubility, and reactivity would be important factors to consider in practical applications.

Formula: C₂₁H₂₈FN₃O₇

InChI: InChI=1/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15?,18-/m0/s1

SMILES: CC(C)[C@@H](C(=N[C@@H](C)C(=NC(CC(=O)O)C(=O)CF)O)O)N=C(O)OCc1ccccc1

Synonyms:

• L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-
• L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-, (S)-
• N-[(Benzyloxy)carbonyl]-L-valyl-N-(1-carboxy-4-fluoro-3-oxobutan-2-yl)-L-alaninamide

Z-Val-Ala-DL-Asp-fluoromethylketone

CAS: 220644-02-0

zVAD-FMK inhibited apoptosis induced by diverse stimuli. Preincubation of cells with this caspase-1 (ICE) inhibitor (50 µM) almost completely inhibited the formation of large kilobase-pair fragments of DNA, a characteristic biochemical change associated with apoptosis. Z-VAD-FMK was shown to irreversibly inhibit most types of caspases, hence it is also called pan-caspase inhibitor. For a cell-permeable analog see N-1560. Inhibitor of peptide:N-glycanase (PNGase).

Formula: C₂₁H₂₈FN₃O₇

Purity: 95.0%

Color and Shape: Beige Lyophilisate

Molecular weight: 453.47

Ref: 01-4026865

Z-VAD-FMK

CAS: 220644-02-0

Z-VAD-FMK

Color and Shape: Solid

Molecular weight: 453.46g/mol

Ref: 54-BIBA1001

Z-Val-Ala-DL-Asp-fluoromethylketone

CAS: 220644-02-0

Z-Val-Ala-DL-Asp-fluoromethylketone is a drug that is used for the treatment of cancer. It can be used in combination with other chemotherapeutic drugs, such as z-vad-fmk, to induce apoptosis in cancer cells. Z-Val-Ala-DL-Asp-fluoromethylketone also inhibits autophagy and neuronal death by inhibiting caspase activation, which prevents the release of proapoptotic proteins from mitochondria into the cytosol. This drug has been shown to have antiinflammatory effects on IL2 receptor signaling pathways and inhibits the production of proinflammatory cytokines by binding to IL2.

Formula: C₂₁H₂₈FN₃O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 453.46 g/mol

Ref: 3D-FV111061

Z-VA-DL-D-FMK

CAS: 220644-02-0

Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) acts as an inhibitor of caspases. It irreversibly binds to caspases, enhancing the sensitivity to TNF-α and stimulating HIV replication in infected T cells ACH-2.

Formula: C₂₁H₂₈FN₃O₇

Color and Shape: Solid

Molecular weight: 453.46

Ref: TM-T88570