CAS 220991-20-8

Lumiracoxib

Description:

Lumiracoxib is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the class of selective cyclooxygenase-2 (COX-2) inhibitors. It is primarily used for the treatment of pain and inflammation associated with osteoarthritis and rheumatoid arthritis. Lumiracoxib exhibits a high selectivity for COX-2 over COX-1, which is intended to reduce gastrointestinal side effects commonly associated with traditional NSAIDs. The chemical structure of lumiracoxib includes a sulfonamide group, which contributes to its pharmacological properties. It is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. However, its use has been associated with potential cardiovascular risks, leading to regulatory scrutiny in some regions. Lumiracoxib is known for its efficacy in managing pain while minimizing gastrointestinal complications, making it a valuable option in pain management protocols. As with any medication, it is essential for patients to consult healthcare professionals regarding its use, potential side effects, and interactions with other medications.

Formula: C₁₅H₁₃ClFNO₂

InChI: InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20)

InChI key: InChIKey=KHPKQFYUPIUARC-UHFFFAOYSA-N

SMILES: N(C1=C(CC(O)=O)C=C(C)C=C1)C2=C(Cl)C=CC=C2F

Synonyms:

• COX 189
• {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
• 2-[(2-Chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic acid
• Prexige
• Benzeneacetic acid, 2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-
• Lumiracoxib

2-(2-((2-Chloro-6-Fluorophenyl)Amino)-5-Methylphenyl)Acetic Acid

CAS: 220991-20-8

2-(2-((2-Chloro-6-Fluorophenyl)Amino)-5-Methylphenyl)Acetic Acid

Formula: C₁₅H₁₃ClFNO₂

Purity: 98%

Molecular weight: 293.72

Ref: 54-PC105134

Lumiracoxib

CAS: 220991-20-8

Formula: C₁₅H₁₃ClFNO₂

Color and Shape: White To Off-White Solid

Molecular weight: 293.73

Ref: 4Z-L-272

Lumiracoxib

CAS: 220991-20-8

Lumiracoxib

Formula: C₁₅H₁₃ClFNO₂

Purity: ≥95%

Molecular weight: 293.72

Ref: 54-BUP11531

Lumiracoxib

CAS: 220991-20-8

Formula: C₁₅H₁₃ClFNO₂

Purity: ≥ 95% (anhydrous basis)

Color and Shape: White, off-white or pale yellow powder

Molecular weight: 293.72

Ref: 7W-GP3550

Lumiracoxib

CAS: 220991-20-8

Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.

Formula: C₁₅H₁₃ClFNO₂

Purity: 96.64% - 99.77%

Color and Shape: Pale Yellow Solid

Molecular weight: 293.72

Ref: TM-T6574

Lumiracoxib

Controlled Product

CAS: 220991-20-8

Applications Lumiracoxib is a selective cyclooxygenase-2-(COX-2) inhibitor and an anti-inflammatory agent (1,2,3,4).
References (1) Bitner, M., et al.: Int. J. Clin. Pract., 58, 340 (2004) (2) Packman, E., et al.: Headache, 45, 1163 (2005) (3) Rordorf, C.M., et al.: Clin. Pharmacokinet., 44. 1247 (2005) (4) Schnitzer, T.J., et al.: Curr. Med. Res. Opin., 21, 151 (2005)

Formula: C₁₅H₁₃ClFNO₂

Color and Shape: Neat

Molecular weight: 293.72

Ref: TR-L474700

Lumiracoxib

Controlled Product

CAS: 220991-20-8

COX2 inhibitor

Formula: C₁₅H₁₃ClFNO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 293.72 g/mol

Ref: 3D-FL24957

Lumiracoxib - Bio-X ™

Controlled Product

CAS: 220991-20-8

Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug that is used for the treatment of osteoarthritis. This drug inhibits prostaglandin synthesis via inhibition of COX-2.

Formula: C₁₅H₁₃ClFNO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 293.72 g/mol

Ref: 3D-BL164650