CAS 220991-32-2

Robenacoxib

Description:

Robenacoxib is a non-steroidal anti-inflammatory drug (NSAID) primarily used in veterinary medicine, particularly for the management of pain and inflammation in dogs and cats. It belongs to the class of selective cyclooxygenase-2 (COX-2) inhibitors, which means it specifically targets the COX-2 enzyme involved in the inflammatory process, thereby reducing pain and swelling with potentially fewer gastrointestinal side effects compared to non-selective NSAIDs. Robenacoxib is characterized by its rapid absorption and metabolism, leading to effective analgesic and anti-inflammatory effects. The substance is typically administered orally or via injection, and its pharmacokinetics allow for once-daily dosing in most cases. As with other NSAIDs, potential side effects may include gastrointestinal upset, renal impairment, and effects on blood clotting, necessitating careful monitoring in clinical use. Overall, Robenacoxib represents a valuable option in the management of acute and chronic pain in companion animals.

Formula: C₁₆H₁₃F₄NO₂

InChI: InChI=1S/C16H13F4NO2/c1-2-8-3-4-12(9(5-8)6-13(22)23)21-16-14(19)10(17)7-11(18)15(16)20/h3-5,7,21H,2,6H2,1H3,(H,22,23)

InChI key: InChIKey=ZEXGDYFACFXQPF-UHFFFAOYSA-N

SMILES: N(C1=C(CC(O)=O)C=C(CC)C=C1)C2=C(F)C(F)=CC(F)=C2F

Synonyms:

• Robenacoxib
• Onsior
• CGS 34975
• 5-Ethyl-2-[(2,3,5,6-tetrafluorophenyl)amino]benzeneacetic acid
• Benzeneacetic acid, 5-ethyl-2-[(2,3,5,6-tetrafluorophenyl)amino]-

Robenacoxib

CAS: 220991-32-2

Robenacoxib (Onsior) is a non-steroidal compound with strong selectivity for cyclooxygenase-2 and anti-inflammatory activity.

Formula: C₁₆H₁₃F₄NO₂

Purity: 99.26%

Color and Shape: Solid

Molecular weight: 327.27

Ref: TM-T26109

Robenacoxib

CAS: 220991-32-2

Robenacoxib

Formula: C₁₆H₁₃F₄NO₂

Purity: ≥98%

Molecular weight: 327.27

Ref: 54-BUP03395

Robenacoxib

CAS: 220991-32-2

Formula: C₁₆H₁₃F₄NO₂

Molecular weight: 327.28

Ref: 4Z-R-154001

Robenacoxib

CAS: 220991-32-2

Color and Shape: Neat

Ref: 61-FOR1400.00

Robenacoxib

CAS: 220991-32-2

2-(5-Ethyl-2-((2,3,5,6-tetrafluorophenyl)amino)phenyl)acetic acid

Formula: C₁₆H₁₃F₄NO₂

Purity: 95+%

Molecular weight: 327.27

Ref: IN-DG00783174

Robenacoxib

CAS: 220991-32-2

Applications A novel COX-2 selective inhibitor, as a nonsteroidal analgesic, anti-inflammatory and antipyretic agent.
References McCormack, K., et al.: Drugs, 41, 533 (1991), Giraudel, J., et al.: Br. J. Pharmacol., 146, 642 (2005), Brune, K., et al.: Rheumatology, 46, 911 (2007),

Formula: C₁₆H₁₃F₄NO₂

Color and Shape: Neat

Molecular weight: 327.27

Ref: TR-R638000

Robenacoxib

CAS: 220991-32-2

Robenacoxib is a non-steroidal anti-inflammatory drug that is used for the treatment of inflammatory bowel disease. It has been shown to inhibit the activity of neurokinin-1 receptor, which has been implicated in the development of bowel disease. The compound has a synergic effect with other drugs, such as aspirin and diclofenac. Robenacoxib is metabolized by cytochrome P450 enzymes and eliminated through glomerular filtration. Clinical pharmacology studies have shown that robenacoxib inhibits phospholipase A2, thereby reducing eicosanoid production and inflammation. END>

Formula: C₁₆H₁₃F₄NO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 327.27 g/mol

Ref: 3D-FR101964

Robenacoxib

CAS: 220991-32-2

Ref: BE-RMCR101000

Robenacoxib

CAS: 220991-32-2

Purity: 95%

Molecular weight: 327.2789917

Ref: 10-F614789

Robenacoxib

CAS: 220991-32-2

Formula: C₁₆H₁₃F₄NO₂

Molecular weight: 327.28

Ref: ST-EA-CP-R28000