CAS 2214-72-4
:N,N'-bis-(2-Chloroethyl)urea
Description:
N,N'-bis-(2-Chloroethyl)urea, with the CAS number 2214-72-4, is an organic compound characterized by its urea structure modified with two chloroethyl groups. This compound typically appears as a white to off-white crystalline solid. It is soluble in polar solvents such as water and alcohols, which is indicative of its ability to engage in hydrogen bonding due to the presence of the urea functional group. The chloroethyl substituents contribute to its reactivity, making it a potential alkylating agent. This compound has been studied for its applications in medicinal chemistry, particularly in the development of anticancer agents, as it can interfere with cellular processes. However, due to the presence of chlorine atoms, it may also pose environmental and health risks, necessitating careful handling and disposal. Its chemical properties, including stability and reactivity, can be influenced by factors such as pH and temperature, which are important considerations in both laboratory and industrial settings.
Formula:C5H10Cl2N2O
InChI:InChI=1S/C20H13NS/c1-3-7-15-13(5-1)9-11-17-19(15)22-20-16-8-4-2-6-14(16)10-12-18(20)21-17/h1-12,21H
SMILES:c1ccc2c(c1)ccc1c2Sc2c3ccccc3ccc2N1
Synonyms:- Urea, N,N'-bis(2-chloroethyl)-
- 1,3-Bis(2-chloroethyl)urea
- Ai3-08682
- Nsc 36198
- Urea, 1,3-bis(2-chloroethyl)-
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Found 9 products.
Carmustine Related Compound A (1,3-bis(2-chloroethyl)urea)
CAS:Acyclic amides (including acyclic carbamates) and their derivatives and salts thereof, nesoiFormula:C5H10Cl2N2OColor and Shape:White PowderMolecular weight:184.01702N,N'-bis-(2-Chloroethyl)urea
CAS:Formula:C5H10Cl2N2OPurity:97%Color and Shape:SolidMolecular weight:185.0517Carmustine EP Impurity A (Carmustine USP Related Compound A)
CAS:Formula:C5H10Cl2N2OMolecular weight:185.051,3-Bis(2-chloroethyl)urea
CAS:<p>1,3-Bis(2-chloroethyl)urea</p>Purity:95%Molecular weight:185.05g/mol1,3-Bis(2-chloroethyl)urea
CAS:<p>Stability Hygroscopic, Unstable in Solution<br>Applications 1,3-Bis(2-chloroethyl)urea is an impurity in the synthesis of Carmustine (C183875), an alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stahl, et al.: Chem. Res. Toxicol., 5, 106 (1992), Kokkinakis, D.M., et al.: Clin. Cancer Res., 5(11), 3676 (1999), Hickman, M.J., et al.: Proc. Natl. Acad. Sci. USA, 96(19), 10764 (1999),<br></p>Formula:C5H10Cl2N2OColor and Shape:NeatMolecular weight:185.05
